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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1981 1
1982 1
1983 1
1984 2
1985 1
1987 1
1988 1
1989 4
1990 3
1991 3
1992 6
1993 2
1994 3
1995 5
1996 4
1997 7
1998 6
1999 11
2000 15
2001 12
2002 19
2003 15
2004 22
2005 32
2006 24
2007 34
2008 38
2009 27
2010 34
2011 64
2012 54
2013 57
2014 63
2015 54
2016 85
2017 95
2018 79
2019 105
2020 113
2021 142
2022 163
2023 159
2024 61

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1,452 results

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Page 1
Anemia: Evaluation and Diagnostic Tests.
Cascio MJ, DeLoughery TG. Cascio MJ, et al. Med Clin North Am. 2017 Mar;101(2):263-284. doi: 10.1016/j.mcna.2016.09.003. Epub 2016 Dec 8. Med Clin North Am. 2017. PMID: 28189170 Review.
Many anemias have characteristic red cell morphology. The reticulocyte count serves as a useful screen for hemolysis or blood loss. Testing for specific causes of the anemia is performed. ...
Many anemias have characteristic red cell morphology. The reticulocyte count serves as a useful screen for hemolysis or blood loss. T …
Physiology, Stress Reaction.
Chu B, Marwaha K, Sanvictores T, Ayers D. Chu B, et al. 2022 Sep 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Sep 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082164 Free Books & Documents.
A stress response is mediated by a complex interplay of nervous, endocrine, and immune mechanisms that involves activation of the sympathetic-adreno-medullar (SAM) axis, the hypothalamus-pituitary-adrenal (HPA) axis, and immune system. The stress response is adaptive, to b …
A stress response is mediated by a complex interplay of nervous, endocrine, and immune mechanisms that involves activation of the sympatheti …
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression.
Gou D, Liu R, Shan X, Deng H, Chen C, Xiang J, Liu Y, Gao Q, Li Z, Huang A, Wang K, Tang N. Gou D, et al. J Clin Invest. 2023 Jul 3;133(13):e161713. doi: 10.1172/JCI161713. J Clin Invest. 2023. PMID: 37166978 Free PMC article.
In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransferase SUV39H1 catalyzed SAM, which served as a methyl donor to support H3K9me3 modificati …
In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serin …
SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.
Zhang J, Zheng YG. Zhang J, et al. ACS Chem Biol. 2016 Mar 18;11(3):583-97. doi: 10.1021/acschembio.5b00812. Epub 2015 Nov 16. ACS Chem Biol. 2016. PMID: 26540123 Free PMC article. Review.
S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of methionine and adenosine. As the second largest cofactor in the human body, its major function is to serve as methyl donor for SAM-dependent methyltransferases (MTases). ...
S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of methionine and adenosine. As the second largest cof …
Radical SAM-mediated methylation reactions.
Fujimori DG. Fujimori DG. Curr Opin Chem Biol. 2013 Aug;17(4):597-604. doi: 10.1016/j.cbpa.2013.05.032. Epub 2013 Jul 5. Curr Opin Chem Biol. 2013. PMID: 23835516 Free PMC article. Review.
Methylcobalamin serves as an intermediate methyl donor in TsrM, and is proposed to transfer the methyl group as a methyl radical. Interestingly, despite the presence of the radical SAM motif, no reductive cleavage of SAM has been observed in this methylation. …
Methylcobalamin serves as an intermediate methyl donor in TsrM, and is proposed to transfer the methyl group as a methyl radical. Int …
SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity.
Lim CY, Lin HT, Kumsta C, Lu TC, Wang FY, Kang YH, Hansen M, Ching TT, Hsu AL. Lim CY, et al. Autophagy. 2023 Jan;19(1):224-240. doi: 10.1080/15548627.2022.2068267. Epub 2022 May 3. Autophagy. 2023. PMID: 35503435 Free PMC article.
While SAMS-1 (S-adenosyl methionine synthetase-1) has been shown to be a key mediator of the DR response, little is known about the roles of S-adenosyl methionine (SAM) and SAM-dependent methyltransferase in autophagy and DR-induced longevity. ...We then find that H …
While SAMS-1 (S-adenosyl methionine synthetase-1) has been shown to be a key mediator of the DR response, little is known about the roles of …
MR1-dependent antigen presentation.
Karamooz E, Harriff MJ, Lewinsohn DM. Karamooz E, et al. Semin Cell Dev Biol. 2018 Dec;84:58-64. doi: 10.1016/j.semcdb.2017.11.028. Semin Cell Dev Biol. 2018. PMID: 30449535 Free PMC article. Review.
Rather, MR1 resides in discrete intracellular vesicles and the endoplasmic reticulum, and can present non-peptidic small molecules such as those found in the riboflavin biosynthesis pathway. Since mammals do not synthesize riboflavin, MR1 can serve as a sensor of the micro …
Rather, MR1 resides in discrete intracellular vesicles and the endoplasmic reticulum, and can present non-peptidic small molecules such as t …
Structure-based insights into recognition and regulation of SAM-sensing riboswitches.
Zheng L, Song Q, Xu X, Shen X, Li C, Li H, Chen H, Ren A. Zheng L, et al. Sci China Life Sci. 2023 Jan;66(1):31-50. doi: 10.1007/s11427-022-2188-7. Epub 2022 Nov 29. Sci China Life Sci. 2023. PMID: 36459353 Review.
SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity, serving as regulatory modules in multiple metabolic pathways. To date, seven SAM-specific riboswitch classes that belong to four families, one …
SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity, serving as …
Epigenetic regulation in the shoot apical meristem.
Nguyen V, Gutzat R. Nguyen V, et al. Curr Opin Plant Biol. 2022 Oct;69:102267. doi: 10.1016/j.pbi.2022.102267. Epub 2022 Aug 16. Curr Opin Plant Biol. 2022. PMID: 35985107 Free article. Review.
Epigenetic mechanisms form the basis of cellular memory, developmental decisions, and the cellular immune system that defends against transposons and viruses. Organs develop from the shoot apical meristem (SAM) to shape the plant's areal phenotype, and stem cells in the …
Epigenetic mechanisms form the basis of cellular memory, developmental decisions, and the cellular immune system that defends against transp …
Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.
Li J, Sun C, Cai W, Li J, Rosen BP, Chen J. Li J, et al. Mutat Res Rev Mutat Res. 2021 Jul-Dec;788:108396. doi: 10.1016/j.mrrev.2021.108396. Epub 2021 Oct 7. Mutat Res Rev Mutat Res. 2021. PMID: 34893161 Free PMC article. Review.
As the second most ubiquitous cofactor in humans, S-adenosyl-l-methionine (SAM or AdoMet) serves as a methyl donor for SAM-dependent methyltransferases (MTases), which transfer a methyl group to a nucleophilic acceptor such as O, As, N, S, or C as the byprodu …
As the second most ubiquitous cofactor in humans, S-adenosyl-l-methionine (SAM or AdoMet) serves as a methyl donor for SAM …
1,452 results