Gastrointestinal drug interactions affecting the elderly

Clin Geriatr Med. 2014 Feb;30(1):1-15. doi: 10.1016/j.cger.2013.10.013.

Abstract

With the burgeoning elderly population in the United States, drug interactions are an increasing concern because of altered drug metabolism associated with age and polypharmacy. This article describes interactions between drugs used in common gastrointestinal diseases, including acid peptic disease, diarrhea, constipation, endoscopic procedural sedation, and inflammatory bowel disease, and those used to treat 5 common geriatric primary care diseases: hypertension, diabetes, hyperlipidemia, arthritis, and psychiatric illnesses.

Keywords: Acid peptic disease; Common gastrointestinal conditions; Constipation; Diarrhea; Drug interactions; Endoscopic procedural sedation; Geriatrics; Inflammatory bowel disease.

Publication types

  • Review

MeSH terms

  • Aged
  • Chronic Disease* / classification
  • Chronic Disease* / drug therapy
  • Chronic Disease* / epidemiology
  • Comorbidity
  • Drug Interactions
  • Gastrointestinal Agents / pharmacology*
  • Gastrointestinal Diseases* / classification
  • Gastrointestinal Diseases* / drug therapy
  • Gastrointestinal Diseases* / epidemiology
  • Health Services Needs and Demand
  • Humans
  • Medication Therapy Management*
  • Polypharmacy
  • Prevalence
  • Primary Health Care* / methods
  • Primary Health Care* / standards
  • Risk Adjustment

Substances

  • Gastrointestinal Agents