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Page 1
Development of Light-Activated LXR Agonists.
Mukhopadhyay TK, Willems S, Arp CJ, Morstein J, Haake CT, Merk D, Trauner D. Mukhopadhyay TK, et al. Among authors: willems s. ChemMedChem. 2023 Jun 1;18(11):e202200647. doi: 10.1002/cmdc.202200647. Epub 2023 Jun 1. ChemMedChem. 2023. PMID: 36896647
Nurr1 Modulation Mediates Neuroprotective Effects of Statins.
Willems S, Marschner JA, Kilu W, Faudone G, Busch R, Duensing-Kropp S, Heering J, Merk D. Willems S, et al. Adv Sci (Weinh). 2022 Jun;9(18):e2104640. doi: 10.1002/advs.202104640. Epub 2022 Apr 30. Adv Sci (Weinh). 2022. PMID: 35488520 Free PMC article.
Design and Structural Optimization of Dual FXR/PPARδ Activators.
Schierle S, Neumann S, Heitel P, Willems S, Kaiser A, Pollinger J, Merk D. Schierle S, et al. Among authors: willems s. J Med Chem. 2020 Aug 13;63(15):8369-8379. doi: 10.1021/acs.jmedchem.0c00618. Epub 2020 Jul 20. J Med Chem. 2020. PMID: 32687365
A New FXR Ligand Chemotype with Agonist/Antagonist Switch.
Helmstädter M, Vietor J, Sommer J, Schierle S, Willems S, Kaiser A, Schmidt J, Merk D. Helmstädter M, et al. Among authors: willems s. ACS Med Chem Lett. 2021 Feb 1;12(2):267-274. doi: 10.1021/acsmedchemlett.0c00647. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603974 Free PMC article.
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. Schierle S, et al. Among authors: willems s. J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878767 Free article.
21 results