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Page 1
Aberrant trafficking of transmembrane proteins in human disease.
Cobbold C, Monaco AP, Sivaprasadarao A, Ponnambalam S. Cobbold C, et al. Trends Cell Biol. 2003 Dec;13(12):639-47. doi: 10.1016/j.tcb.2003.10.008. Trends Cell Biol. 2003. PMID: 14624842 Review.
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, tra …
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracell …
Searching for Street Parking: Effects on Driver Vehicle Control, Workload, Physiology, and Glances.
Ponnambalam CT, Donmez B. Ponnambalam CT, et al. Front Psychol. 2020 Oct 20;11:574262. doi: 10.3389/fpsyg.2020.574262. eCollection 2020. Front Psychol. 2020. PMID: 33192873 Free PMC article.
A detailed analysis of eye-tracking data revealed a clear change in glance behavior while searching for parking, with an increase in long off-road glances (>2 s) and decrease in shorter off-road glances (<1.6 s). Some exhibited behaviors (e.g., slowing …
A detailed analysis of eye-tracking data revealed a clear change in glance behavior while searching for parking, with an increase in long of …
Activation of cytosolic phospholipase A2-{alpha} as a novel mechanism regulating endothelial cell cycle progression and angiogenesis.
Herbert SP, Odell AF, Ponnambalam S, Walker JH. Herbert SP, et al. J Biol Chem. 2009 Feb 27;284(9):5784-96. doi: 10.1074/jbc.M807282200. Epub 2009 Jan 1. J Biol Chem. 2009. PMID: 19119141 Free PMC article.
Using a combination of chemical inhibition, loss of function, and gain of function approaches, we demonstrate that endothelial cell cycle re-entry, S phase progression, and subsequent angiogenic tubule formation are dependent upon the activity of cytosolic phospholipase A( …
Using a combination of chemical inhibition, loss of function, and gain of function approaches, we demonstrate that endothelial cell cycle re …
Evolution of the VEGF-regulated vascular network from a neural guidance system.
Ponnambalam S, Alberghina M. Ponnambalam S, et al. Mol Neurobiol. 2011 Jun;43(3):192-206. doi: 10.1007/s12035-011-8167-3. Epub 2011 Jan 28. Mol Neurobiol. 2011. PMID: 21271303
We propose that the VEGF-VEGFR axis was subverted by evolution to mediate the formation of biological tubes necessary for transport of fluids, e.g., blood. Increasingly, there is evidence that aberrant VEGF-mediated responses are also linked to neuronal dysfunctions rangin …
We propose that the VEGF-VEGFR axis was subverted by evolution to mediate the formation of biological tubes necessary for transport of fluid …
Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the Ig(alpha)/Ig(beta) dimer.
Knight AM, Lucocq JM, Prescott AR, Ponnambalam S, Watts C. Knight AM, et al. EMBO J. 1997 Jul 1;16(13):3842-50. doi: 10.1093/emboj/16.13.3842. EMBO J. 1997. PMID: 9233794 Free PMC article.
Thus, unlike mIgM, mIgG has autonomous antigen capture and presentation capacity, which may have evolved to reduce or eliminate the BCR's dependence on additional accessory molecules....
Thus, unlike mIgM, mIgG has autonomous antigen capture and presentation capacity, which may have evolved to reduce or eliminate the BCR's …
Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells.
Latham AM, Bruns AF, Kankanala J, Johnson AP, Fishwick CW, Homer-Vanniasinkam S, Ponnambalam S. Latham AM, et al. Br J Pharmacol. 2012 Jan;165(1):245-59. doi: 10.1111/j.1476-5381.2011.01545.x. Br J Pharmacol. 2012. PMID: 21699503 Free PMC article.
BACKGROUND AND PURPOSE: The potent pro-angiogenic growth factors VEGF-A and basic fibroblast growth factor (bFGF) exert their effects by binding VEGF receptor 2 and FGF receptor tyrosine kinases, respectively. Indolinones (e.g. SU5416 and Sutent) and anilinophthalazines (e …
BACKGROUND AND PURPOSE: The potent pro-angiogenic growth factors VEGF-A and basic fibroblast growth factor (bFGF) exert their effects by bin …
Mutations that reduce expression from the P2 promoter of the Escherichia coli galactose operon.
Bingham AH, Ponnambalam S, Chan B, Busby S. Bingham AH, et al. Gene. 1986;41(1):67-74. doi: 10.1016/0378-1119(86)90268-4. Gene. 1986. PMID: 3516794
The effects of the two strongest P2 mutations were investigated in the absence of the P1 mutation used for their isolation. One mutation, a T:A to C:G transition at -12, inactivates both P2 and P1. In contrast the other, a T:A to G:C transversion at -19, specificall …
The effects of the two strongest P2 mutations were investigated in the absence of the P1 mutation used for their isolation. One mutation, a …