Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis.
Neupane AS, Willson M, Chojnacki AK, Vargas E Silva Castanheira F, Morehouse C, Carestia A, Keller AE, Peiseler M, DiGiandomenico A, Kelly MM, Amrein M, Jenne C, Thanabalasuriar A, Kubes P.
Neupane AS, et al.
Cell. 2020 Oct 1;183(1):110-125.e11. doi: 10.1016/j.cell.2020.08.020. Epub 2020 Sep 3.
Cell. 2020.
PMID: 32888431
Free article.
Importantly, these macrophages sensed, chemotaxed, and, with high efficiency, phagocytosed inhaled bacterial pathogens such as P. aeruginosa and S. aureus, cloaking the bacteria from neutrophils. Impairing AM chemotaxis toward bacteria induced superfluous neutrophil recrui …
Importantly, these macrophages sensed, chemotaxed, and, with high efficiency, phagocytosed inhaled bacterial pathogens such as P. aeruginosa …