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Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries.
NIHR Global Health Unit on Global Surgery; COVIDSurg Collaborative. NIHR Global Health Unit on Global Surgery, et al. Lancet. 2022 Nov 5;400(10363):1607-1617. doi: 10.1016/S0140-6736(22)01846-3. Epub 2022 Oct 31. Lancet. 2022. PMID: 36328042 Free PMC article.
In the mixed-effects model, a 10-point increase in SPI corresponded to a 3.6% (95% CI 3.0-4.1; p<0.0001) increase in SVR. This was consistent in HIC (4.8% [4.1-5.5]; p<0.0001), MIC (2.8 [2.0-3.7]; p<0.0001), and LIC (3.8 [1.3-6.7%]; p<0.000 …
In the mixed-effects model, a 10-point increase in SPI corresponded to a 3.6% (95% CI 3.0-4.1; p<0.0001) increase in SVR. This was …
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.
COVIDSurg Collaborative. COVIDSurg Collaborative. Lancet Oncol. 2021 Nov;22(11):1507-1517. doi: 10.1016/S1470-2045(21)00493-9. Epub 2021 Oct 5. Lancet Oncol. 2021. PMID: 34624250 Free PMC article. Clinical Trial.
Light restrictions were associated with a 0.6% non-operation rate (26 of 4521), moderate lockdowns with a 5.5% rate (201 of 3646; adjusted hazard ratio [HR] 0.81, 95% CI 0.77-0.84; p<0.0001), and full lockdowns with a 15.0% rate (1775 of 11 827; HR 0.51, 0.50-0.53; p …
Light restrictions were associated with a 0.6% non-operation rate (26 of 4521), moderate lockdowns with a 5.5% rate (201 of 3646; adjusted h …
Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis.
Lather A, Sharma S, Khatkar A. Lather A, et al. BMC Chem. 2020 Jun 19;14(1):41. doi: 10.1186/s13065-020-00693-3. eCollection 2020 Dec. BMC Chem. 2020. PMID: 32577624 Free PMC article.
The antimicrobial activity of synthesized compounds revealed compound 1 as the most potent compound (pMIC 1.79, 1.79, 1.49, 1.49, 1.49 and 1.49 muM/mL for P. mirabilis, P. aeruginosa, S. aureus, E. coli, C. albicans and A. niger respectively) as compared to s …
The antimicrobial activity of synthesized compounds revealed compound 1 as the most potent compound (pMIC 1.79, 1.79, 1.49, 1.49, 1.49 and 1 …
Analysis of introgression of Aegilops ventricosa Tausch. genetic material in a common wheat background using C-banding.
Badaeva ED, Dedkova OS, Koenig J, Bernard S, Bernard M. Badaeva ED, et al. Theor Appl Genet. 2008 Sep;117(5):803-11. doi: 10.1007/s00122-008-0821-4. Epub 2008 Jul 3. Theor Appl Genet. 2008. PMID: 18597067
However, the translocation of the 2N(v)/6N(v) chromosome of A. ventricosa to the short arm of the 2A chromosome of wheat that had been identified in an earlier study using molecular analysis (Bonhomme A, Gale MD, Koebner RMD, Nicolas P, Jahier J, Bernard M in Theor Appl Ge …
However, the translocation of the 2N(v)/6N(v) chromosome of A. ventricosa to the short arm of the 2A chromosome of wheat that had been ident …
The outcomes of total hip replacement in osteonecrosis versus osteoarthritis: a systematic review and meta-analysis.
Salman LA, Hantouly AT, Khatkar H, Al-Ani A, Abudalou A, Al-Juboori M, Ahmed G. Salman LA, et al. Int Orthop. 2023 Dec;47(12):3043-3052. doi: 10.1007/s00264-023-05761-6. Epub 2023 Mar 11. Int Orthop. 2023. PMID: 36905418 Free PMC article. Review.
There was a statistically significant difference in revision rate between ON and OA patients in favour of OA (OR: 1.576; 95%CI: 1.24-2.00; p-value: 0.0015). However, dislocation rate (OR: 1.5004; 95%CI: 0.92-2.43; p-value: 0.0916) and Haris hip score (HHS) (SMD: - 0 …
There was a statistically significant difference in revision rate between ON and OA patients in favour of OA (OR: 1.576; 95%CI: 1.24-2.00; …
Virtual Screening of Novel Glucosamine-6-Phosphate Synthase Inhibitors.
Lather A, Sharma S, Khatkar A. Lather A, et al. Comb Chem High Throughput Screen. 2018;21(3):182-193. doi: 10.2174/1386207321666180330114457. Comb Chem High Throughput Screen. 2018. PMID: 29600755
RESULTS: Molecular docking studies were carried out to identify the binding affinities and interaction between the inhibitors and the target proteins (G-6-P synthase) by using Glide software (Schrodinger Inc. U.S.A.-Maestro version 10.2). ...These G-6-P synth …
RESULTS: Molecular docking studies were carried out to identify the binding affinities and interaction between the inhibitors and the target …
Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation.
Lather A, Sharma S, Khatkar A. Lather A, et al. Sci Rep. 2020 Nov 24;10(1):20477. doi: 10.1038/s41598-020-77511-2. Sci Rep. 2020. PMID: 33235242 Free PMC article.
Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis. In recent year's demand of preservatives for the food, cosmetics and pharmaceuticals have increased. ...Resultant dat …
Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell …
Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products.
Lather A, Sharma S, Khatkar A. Lather A, et al. Sci Rep. 2020 Aug 17;10(1):13903. doi: 10.1038/s41598-020-70895-1. Sci Rep. 2020. PMID: 32807915 Free PMC article.
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. ...Moreover, the mechanistic insight into the docking poses has also been explored by binding interactions of amygdalin derivative …
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial …
Dietary patterns in North and South India: a comparison with EAT-Lancet dietary recommendations.
Ganpule A, Dubey M, Pandey H, Green R, Brown KA, Srinivasapura Venkateshmurthy N, Jarhyan P, Maddury AP, Khatkar R, Prabhakaran D, Mohan S. Ganpule A, et al. J Hum Nutr Diet. 2023 Dec;36(6):2170-2179. doi: 10.1111/jhn.13222. Epub 2023 Aug 9. J Hum Nutr Diet. 2023. PMID: 37555567

For whole grains, female gender and poorest wealth index were the factors associated with deficit or no consumption, whereas, for vegetables and fruits, it was poorest wealth index and residence in rural areas (p < 0.05, all). Rural residence and poorest wealth index we

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For whole grains, female gender and poorest wealth index were the factors associated with deficit or no consumption, whereas, for vegetables …
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.
COVIDSurg Collaborative. COVIDSurg Collaborative. Br J Surg. 2021 Jan 27;108(1):88-96. doi: 10.1093/bjs/znaa051. Br J Surg. 2021. PMID: 33640908 Free PMC article.
After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. ...
After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence …
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