S. Ken Tanaka - Search Results

Year	Number of Results
2006	1
2009	1
2010	2
2012	1
2015	1
2016	6
2017	5
2019	1
2020	2
2021	2
2022	3
2024	0

1

Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic.

Tanaka SK, Steenbergen J, Villano S. Tanaka SK, et al. Bioorg Med Chem. 2016 Dec 15;24(24):6409-6419. doi: 10.1016/j.bmc.2016.07.029. Epub 2016 Jul 18. Bioorg Med Chem. 2016. PMID: 27469981 Free article. Review.

2

Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation.

Bunick CG, Keri J, Tanaka SK, Furey N, Damiani G, Johnson JL, Grada A. Bunick CG, et al. Among authors: tanaka sk. Antibiotics (Basel). 2021 Apr 15;10(4):439. doi: 10.3390/antibiotics10040439. Antibiotics (Basel). 2021. PMID: 33920812 Free PMC article. Review.

3

Sub-growth-inhibitory concentrations of omadacycline inhibit Staphylococcus aureus haemolytic activity in vitro.

Serio AW, Tanaka SK, Wright K, Garrity-Ryan L. Serio AW, et al. Among authors: tanaka sk. JAC Antimicrob Resist. 2021 Dec 22;4(1):dlab190. doi: 10.1093/jacamr/dlab190. eCollection 2022 Mar. JAC Antimicrob Resist. 2021. PMID: 34988444 Free PMC article.

4

Structure-activity relationship of the aminomethylcyclines and the discovery of omadacycline.

Honeyman L, Ismail M, Nelson ML, Bhatia B, Bowser TE, Chen J, Mechiche R, Ohemeng K, Verma AK, Cannon EP, Macone A, Tanaka SK, Levy S. Honeyman L, et al. Among authors: tanaka sk. Antimicrob Agents Chemother. 2015 Nov;59(11):7044-53. doi: 10.1128/AAC.01536-15. Epub 2015 Sep 8. Antimicrob Agents Chemother. 2015. PMID: 26349824 Free PMC article.

5

Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity.

Grada A, Del Rosso JQ, Moore AY, Stein Gold L, Harper J, Damiani G, Shaw K, Obagi S, Salem RJ, Tanaka SK, Bunick CG. Grada A, et al. Among authors: tanaka sk. Front Med (Lausanne). 2022 Dec 8;9:1033980. doi: 10.3389/fmed.2022.1033980. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36569144 Free PMC article.

6

In Vitro and In Vivo Assessments of Cardiovascular Effects with Omadacycline.

Tanaka SK, Villano S. Tanaka SK, et al. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5247-53. doi: 10.1128/AAC.00320-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27324778 Free PMC article.

7

Effect of Food on the Bioavailability of Omadacycline in Healthy Participants.

Tzanis E, Manley A, Villano S, Tanaka SK, Bai S, Loh E. Tzanis E, et al. Among authors: tanaka sk. J Clin Pharmacol. 2017 Mar;57(3):321-327. doi: 10.1002/jcph.814. Epub 2016 Sep 22. J Clin Pharmacol. 2017. PMID: 27539539 Free PMC article. Clinical Trial.

8

Activity of omadacycline in vitro against Clostridioides difficile and preliminary efficacy assessment in a hamster model of C. difficile-associated diarrhoea.

Leahy RG, Serio AW, Wright K, Traczewski MM, Tanaka SK. Leahy RG, et al. Among authors: tanaka sk. J Glob Antimicrob Resist. 2022 Sep;30:96-99. doi: 10.1016/j.jgar.2022.04.019. Epub 2022 Apr 29. J Glob Antimicrob Resist. 2022. PMID: 35500838 Free article.

9

An Open-Label Study of the Impact of Hepatic Impairment on the Pharmacokinetics and Safety of Single Oral and Intravenous Doses of Omadacycline.

Kovacs SJ, Ting L, Praestgaard J, Sunkara G, Sun H, Stein DS, Tanaka SK, Villano S. Kovacs SJ, et al. Among authors: tanaka sk. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01650-20. doi: 10.1128/AAC.01650-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32839218 Free PMC article.

10

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.

Flarakos J, Du Y, Gu H, Wang L, Einolf HJ, Chun DY, Zhu B, Alexander N, Natrillo A, Hanna I, Ting L, Zhou W, Dole K, Sun H, Kovacs SJ, Stein DS, Tanaka SK, Villano S, Mangold JB. Flarakos J, et al. Among authors: tanaka sk. Xenobiotica. 2017 Aug;47(8):682-696. doi: 10.1080/00498254.2016.1213465. Epub 2016 Aug 8. Xenobiotica. 2017. PMID: 27499331

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