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Page 1
Showing results for S. K. tawfik
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. Ridker PM, et al. N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27. N Engl J Med. 2017. PMID: 28845751 Free article. Clinical Trial.
Current Trends in Endoscopic Ear Surgery.
Tu LJ, Fina M, Golub JS, Kazahaya K, Quesnel AM, Tawfik KO, Cohen MS. Tu LJ, et al. Otol Neurotol Open. 2022 Dec 2;2(4):e023. doi: 10.1097/ONO.0000000000000023. eCollection 2022 Dec. Otol Neurotol Open. 2022. PMID: 38516579 Free PMC article. No abstract available.
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19.
ISARIC Clinical Characterization Group; Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. ISARIC Clinical Characterization Group, et al. Sci Data. 2022 Jul 30;9(1):454. doi: 10.1038/s41597-022-01534-9. Sci Data. 2022. PMID: 35908040 Free PMC article.
An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.
Sabt A, Tawfik HO, Khaleel EF, Badi RM, Ibrahim HAA, Elkaeed EB, Eldehna WM. Sabt A, et al. Mol Divers. 2024 Jan 30. doi: 10.1007/s11030-023-10777-6. Online ahead of print. Mol Divers. 2024. PMID: 38289431 Review.
Inhibitors are made to suppress the oncogenic K-RAS G12C mutant only when the nucleophilic cysteine residue at codon 12 is present and many inhibitors with various mechanisms like breaking the organization membrane of K-RAS nano-clustering. So, this is a thorough an …
Inhibitors are made to suppress the oncogenic K-RAS G12C mutant only when the nucleophilic cysteine residue at codon 12 is present an …
Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease.
Tawfik A, Flanagan PK, Campbell BJ. Tawfik A, et al. World J Gastroenterol. 2014 Jul 21;20(27):8751-63. doi: 10.3748/wjg.v20.i27.8751. World J Gastroenterol. 2014. PMID: 25083050 Free PMC article. Review.
Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn's disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. ...Here we review the current under …
Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn's disease (CD) …
Efficient and selective p-nitrophenyl-ester-hydrolyzing antibodies elicited by a p-nitrobenzyl phosphonate hapten.
Tawfik DS, Lindner AB, Chap R, Eshhar Z, Green BS. Tawfik DS, et al. Eur J Biochem. 1997 Mar 1;244(2):619-26. doi: 10.1111/j.1432-1033.1997.00619.x. Eur J Biochem. 1997. PMID: 9119032 Free article.
Unexpectedly, the affinity to the Np-ester substrate (1/K(M)) and therefore k(cat)/K(M) are significantly higher. The best example is antibody D2.4 having a k(cat)/K(M) value of 64 s(-1) x M(-1) with the Nbzl-ester and 9400 s(-1) x …
Unexpectedly, the affinity to the Np-ester substrate (1/K(M)) and therefore k(cat)/K(M) are significantly higher. The b …
Beam-Energy Dependence of Directed Flow of lambda, lambda[over ], K^{}, K_{s}^{0}, and in Au+Au Collisions.
Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Ajitanand NN, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Attri A, Averichev GS, Bai X, Bairathi V, Barish K, Behera A, Bellwied R, Bhasin A, Bhati AK, Bhattarai P, Bielcik J, Bielcikova J, Bland LC, Bordyuzhin IG, Bouchet J, Brandenburg JD, Brandin AV, Brown D, Bunzarov I, Butterworth J, Caines H, Calderón de la Barca Sánchez M, Campbell JM, Cebra D, Chakaberia I, Chaloupka P, Chang Z, Chankova-Bunzarova N, Chatterjee A, Chattopadhyay S, Chen X, Chen JH, Chen X, Cheng J, Cherney M, Christie W, Contin G, Crawford HJ, Das S, De Silva LC, Dedovich TG, Deng J, Derevschikov AA, Didenko L, Dilks C, Dong X, Drachenberg JL, Draper JE, Dunkelberger LE, Dunlop JC, Efimov LG, Elsey N, Engelage J, Eppley G, Esha R, Esumi S, Evdokimov O, Ewigleben J, Eyser O, Fatemi R, Fazio S, Federic P, Federicova P, Fedorisin J, Feng Z, Filip P, Finch E, Fisyak Y, Flores CE, Fujita J, Fulek L, Gagliardi CA, Garand D, Geurts F, Gibson A, Girard M, Grosnick D, Gunarathne DS, Guo Y, Gupta A, Gupta S, Guryn W, Hamad AI, Hamed A, Harlenderova A, Harris JW, He L, Heppelmann S, Heppelmann S, Hirsch A, Ho… See abstract for full author list ➔ Adamczyk L, et al. Phys Rev Lett. 2018 Feb 9;120(6):062301. doi: 10.1103/PhysRevLett.120.062301. Phys Rev Lett. 2018. PMID: 29481217
Rapidity-odd directed-flow measurements at midrapidity are presented for lambda, lambda[over ], K^{}, K_{s}^{0}, and at sqrt[s_{NN}]=7.7, 11.5, 14.5, 19.6, 27, 39, 62.4, and 200 GeV in Au+Au collisions recorded by the Solenoidal Tracker detector at the …
Rapidity-odd directed-flow measurements at midrapidity are presented for lambda, lambda[over ], K^{}, K_{s}^{0}, and at …
Kemp elimination catalysts by computational enzyme design.
Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Röthlisberger D, et al. Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19. Nature. 2008. PMID: 18354394
Application of in vitro evolution to enhance the computational designs produced a >200-fold increase in k(cat)/K(m) (k(cat)/K(m) of 2,600 M(-1)s(-1) and k(cat)/k(uncat) of >10(6)). ...
Application of in vitro evolution to enhance the computational designs produced a >200-fold increase in k(cat)/K(m) (k …
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