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Anti-proliferative and antitumor activity of organotin(IV) compounds. An overview of the last decade and future perspectives.
Banti CN, Hadjikakou SK, Sismanoglu T, Hadjiliadis N. Banti CN, et al. J Inorg Biochem. 2019 May;194:114-152. doi: 10.1016/j.jinorgbio.2019.02.003. Epub 2019 Feb 13. J Inorg Biochem. 2019. PMID: 30851663 Review.
The period covered by this work goes back to 2009 until late 2018, while the earlier ones, are included over the previous review of our group published by S.K. Hadjikakou, N. Hadjiliadis, in Coord Chem Rev, 253 (2009) 235-249. ...
The period covered by this work goes back to 2009 until late 2018, while the earlier ones, are included over the previous review of our grou …
A global land cover training dataset from 1984 to 2020.
Stanimirova R, Tarrio K, Turlej K, McAvoy K, Stonebrook S, Hu KT, Arévalo P, Bullock EL, Zhang Y, Woodcock CE, Olofsson P, Zhu Z, Barber CP, Souza CM Jr, Chen S, Wang JA, Mensah F, Calderón-Loor M, Hadjikakou M, Bryan BA, Graesser J, Beyene DL, Mutasha B, Siame S, Siampale A, Friedl MA. Stanimirova R, et al. Sci Data. 2023 Dec 7;10(1):879. doi: 10.1038/s41597-023-02798-5. Sci Data. 2023. PMID: 38062043 Free PMC article.
New metalo-therapeutics of NSAIDs against human breast cancer cells.
Banti CN, Papatriantafyllopoulou C, Tasiopoulos AJ, Hadjikakou SK. Banti CN, et al. Eur J Med Chem. 2018 Jan 1;143:1687-1701. doi: 10.1016/j.ejmech.2017.10.067. Epub 2017 Nov 11. Eur J Med Chem. 2018. PMID: 29133038
The non steroidal anti-inflammatory drugs (NSAID's)-silver(I) metallodrugs of aspirin (aspH), salicylic acid (salH(2)), naproxen (napH) acid or p-hydrobenzoic acid (pHbzaH) and the mitochondriotropic triphenylarsine (tpAs) with the formulae [Ag(asp)(tpAs)(3)] (1), [Ag(salH …
The non steroidal anti-inflammatory drugs (NSAID's)-silver(I) metallodrugs of aspirin (aspH), salicylic acid (salH(2)), naproxen (nap …
Diclofenac conjugates with biocides through silver(I) ions (CoMeD's); Development of a reliable model for the prediction of anti-proliferation of NSAID's-silver formulations.
Banti CN, Hatzidimitriou AG, Kourkoumelis N, Hadjikakou SK. Banti CN, et al. J Inorg Biochem. 2019 May;194:7-18. doi: 10.1016/j.jinorgbio.2019.01.020. Epub 2019 Feb 17. J Inorg Biochem. 2019. PMID: 30798079
The conjugation of diclofenac (DICLH), a Non-Steroidal Anti-inflammatory Drug (NSAID), with biocides such as dimethyl sulfoxide (DMSO) and triphenylphosphine (TPP), through silver(I) ions, results into the chemical [Ag(n)(DICL)(n)(L)(m)](k) (L = DMSO and n = 2, m = 2, k …
The conjugation of diclofenac (DICLH), a Non-Steroidal Anti-inflammatory Drug (NSAID), with biocides such as dimethyl sulfoxide (DMSO) and t …
Novel metallo-therapeutics of the NSAID naproxen. Interaction with intracellular components that leads the cells to apoptosis.
Banti CN, Giannoulis AD, Kourkoumelis N, Owczarzak AM, Kubicki M, Hadjikakou SK. Banti CN, et al. Dalton Trans. 2014 May 14;43(18):6848-63. doi: 10.1039/c3dt53175a. Dalton Trans. 2014. PMID: 24658365
The binding affinity of 1-2 towards the intracellular molecules CT-DNA and lipoxygenase (LOX) was studied for the evaluation of the mechanism of cell death. Thus, the binding constants (K(b)) of 1-2 towards CT-DNA calculated by UV-Vis spectra are 32.8 8.5 10(4) (1) and 4.7 …
The binding affinity of 1-2 towards the intracellular molecules CT-DNA and lipoxygenase (LOX) was studied for the evaluation of the mechanis …
Synthesis, characterization, and binding properties towards CT-DNA and lipoxygenase of mixed-ligand silver(I) complexes with 2-mercaptothiazole and its derivatives and triphenylphosphine.
Kyros L, Banti CN, Kourkoumelis N, Kubicki M, Sainis I, Hadjikakou SK. Kyros L, et al. J Biol Inorg Chem. 2014 Mar;19(3):449-64. doi: 10.1007/s00775-014-1089-6. Epub 2014 Jan 21. J Biol Inorg Chem. 2014. PMID: 24445998
Changes in the fluorescence of ethidium bromide in the presence of DNA suggest intercalation into or electrostatic interactions with DNA. The corresponding apparent binding constants (K app) towards CT-DNA calculated through fluorescence spectra are (3.5 0.7) 10(4) M(-1) f …
Changes in the fluorescence of ethidium bromide in the presence of DNA suggest intercalation into or electrostatic interactions with DNA. Th …
Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2-mercaptobenzothiazole and 2-mercaptonicotinic acid.
Xanthopoulou MN, Hadjikakou SK, Hadjiliadis N, Schürmann M, Jurkschat K, Michaelides A, Skoulika S, Bakas T, Binolis J, Karkabounas S, Charalabopoulos K. Xanthopoulou MN, et al. J Inorg Biochem. 2003 Aug 1;96(2-3):425-34. doi: 10.1016/s0162-0134(03)00178-8. J Inorg Biochem. 2003. PMID: 12888279
Crystal structures of molecules 1, 3 and 5 have been determined by X-ray diffraction at 173(1) K (1 and 5) and 293(2) K (3). Compound 1 C(22)H(26)N(2)S(4)Sn, is monoclinic, space group C2/c, a=44.018(2), b=8.8864(5), c=12.8633(7) A, beta=104.195(5) degrees, Z …
Crystal structures of molecules 1, 3 and 5 have been determined by X-ray diffraction at 173(1) K (1 and 5) and 293(2) K (3). C …
Synthesis, structural characterization and biological studies of the triphenyltin(IV) complex with 2-thiobarbituric acid.
Balas VI, Verginadis II, Geromichalos GD, Kourkoumelis N, Male L, Hursthouse MB, Repana KH, Yiannaki E, Charalabopoulos K, Bakas T, Hadjikakou SK. Balas VI, et al. Eur J Med Chem. 2011 Jul;46(7):2835-44. doi: 10.1016/j.ejmech.2011.04.005. Epub 2011 Apr 8. Eur J Med Chem. 2011. PMID: 21521629
The crystal structure of complex 1 has been determined by X-ray diffraction at 120 K. Complex 1 is polymeric. The geometry around the tin(IV) ions is trigonal bi-pyramidal with coordination to three C atoms from phenyl groups and one O atom from a de-protonated HTBA ligand …
The crystal structure of complex 1 has been determined by X-ray diffraction at 120 K. Complex 1 is polymeric. The geometry around the …
Synthesis, structural characterization, and biological studies of six- and five-coordinate organotin(IV) complexes with the thioamides 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, and 2-mercaptobenzoxazole.
Xanthopoulou MN, Hadjikakou SK, Hadjiliadis N, Kubicki M, Skoulika S, Bakas T, Baril M, Butler IS. Xanthopoulou MN, et al. Inorg Chem. 2007 Feb 19;46(4):1187-95. doi: 10.1021/ic061601f. Inorg Chem. 2007. PMID: 17291115
The crystal structures of complexes 1, 3, and 4 were determined by X-ray diffraction at room temperature [295(1) or 293(2) K]. The complexes [(C6H5)3Sn(mbzo)] (2) and [(n-C4H9)2Sn(cmbzt)2] (5) (Hmbzo = 2-mercaptobenzoxazole) were synthesized by new improved methods, and th …
The crystal structures of complexes 1, 3, and 4 were determined by X-ray diffraction at room temperature [295(1) or 293(2) K]. The co …
Structural motifs of diiodine complexes with amides and thioamides.
Parigoridi IE, Corban GJ, Hadjikakou SK, Hadjiliadis N, Kourkoumelis N, Kostakis G, Psycharis V, Raptopoulou CP, Kubicki M. Parigoridi IE, et al. Dalton Trans. 2008 Oct 14;(38):5159-65. doi: 10.1039/b805825c. Epub 2008 Aug 19. Dalton Trans. 2008. PMID: 18813369
The crystal structure of 1 was also determined by X-ray diffraction at 294(1) K. Compound 1 is monoclinic, space group P2(1)/n, consisting of two cationic [PMOH(2)](+) species and a [I(2)Cl(2)](2-) counter dianion. ...Direct reaction of thiazolidine-2-thione (tzdtH), with …
The crystal structure of 1 was also determined by X-ray diffraction at 294(1) K. Compound 1 is monoclinic, space group P2(1)/n, consi …