Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.
Fan H, Xia S, Xiang J, Li Y, Ross MO, Lim SA, Yang F, Tu J, Xie L, Dougherty U, Zhang FQ, Zheng Z, Zhang R, Wu R, Dong L, Su R, Chen X, Althaus T, Riedell PA, Jonker PB, Muir A, Lesinski GB, Rafiq S, Dhodapkar MV, Stock W, Odenike O, Patel AA, Opferman J, Tsuji T, Matsuzaki J, Shah H, Faubert B, Elf SE, Layden B, Bissonnette BM, He YY, Kline J, Mao H, Odunsi K, Gao X, Chi H, He C, Chen J.
Fan H, et al.
Nature. 2023 Nov;623(7989):1034-1043. doi: 10.1038/s41586-023-06749-3. Epub 2023 Nov 22.
Nature. 2023.
PMID: 37993715
Free PMC article.
Circulating TVA in humans is mainly from ruminant-derived foods including beef, lamb and dairy products such as milk and butter(2,3), but only around 19% or 12% of dietary TVA is converted to rumenic acid by humans or mice, respectively(4,5). Mechanistically, TVA inactivat …
Circulating TVA in humans is mainly from ruminant-derived foods including beef, lamb and dairy products such as milk and butter(2,3), but on …