Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer.
Grünwald B, Vandooren J, Locatelli E, Fiten P, Opdenakker G, Proost P, Krüger A, Lellouche JP, Israel LL, Shenkman L, Comes Franchini M.
Grünwald B, et al.
J Control Release. 2016 Oct 10;239:39-48. doi: 10.1016/j.jconrel.2016.08.016. Epub 2016 Aug 19.
J Control Release. 2016.
PMID: 27545397
The specific MMP-9-cleavable linker was designed based on the degradation efficiency of peptides derived from the collagen type II sequence. MMP-9-dependent uptake of the Magh@PNPs-PEG-RegaCP-PEG was demonstrated in pancreatic cancer cells in vitro. ...Pre-treatment of mic …
The specific MMP-9-cleavable linker was designed based on the degradation efficiency of peptides derived from the collagen type II sequence. …