To study the effect of microgravity on peripheral oxygen saturation (SpO 2) in rats, tail-suspended rats were applied to simulate microgravity environment. SpO 2 and arterial oxygen saturation (SaO 2) were measured by pulse oximeter and arterial blood gas analyzer (ABGA) respectively on the 14th day, 21st day and 28th day in tail-suspended group and control group. Paired t-test shows that SpO 2 was significantly lower than SaO 2 in tail-suspended group on the 14th day ( P < 0.05), the 21st day ( P < 0.05) and the 28th day ( P < 0.01). The ANOVA results shows that modeling time had significant effect on SpO 2 value but no effect on SaO 2 value in tail-suspended group. These results indicate that pulse oximeter may be not suitable for oxygen saturation test in microgravity environment.
本论文旨在通过大鼠尾部悬吊方式建立模拟微重力动物模型，研究微重力环境对无创方法测量大鼠血氧饱和度结果的影响。分别在饲养第 14 天、21 天和 28 天使用脉搏血氧仪、血气分析仪测量实验组、对照组大鼠的脉搏血氧饱和度（SpO 2）及动脉血氧饱和度（SaO 2）。配对 t 检验结果显示，与对照组相比，实验组大鼠的 SpO 2 在第 14 天（ P < 0.05）、21 天（ P < 0.05）和 28 天（ P < 0.05）均明显低于 SaO 2 值。方差分析结果显示，SpO 2 值与造模时间有关，而 SaO 2 值与造模时间无关。上述结果表明，现有常规脉搏血氧仪可能不适用于空间微重力环境下的血氧饱和度测量。.
Keywords: SaO2; SpO2; pulse oximeter; simulated microgravity; space medical engineering.