The Role of MicroRNA-206 in the Regulation of Diabetic Wound Healing via Hypoxia-Inducible Factor 1-Alpha

Zeming Bai; Dapeng Zhou; Kai Tao; Feng Lin; Hongyi Wang; Haiwei Sun; Ruidi Liu; Zhe Li

doi:10.1007/s10528-024-10759-9

The Role of MicroRNA-206 in the Regulation of Diabetic Wound Healing via Hypoxia-Inducible Factor 1-Alpha

Biochem Genet. 2024 Mar 6. doi: 10.1007/s10528-024-10759-9. Online ahead of print.

Authors

Zeming Bai¹, Dapeng Zhou², Kai Tao³, Feng Lin¹, Hongyi Wang¹, Haiwei Sun¹, Ruidi Liu¹, Zhe Li¹

Affiliations

¹ Burn and Plastic Surgery Department, General Hospital of Northern Theater Command, Shenyang, 110000, China.
² Burn and Plastic Surgery Department, General Hospital of Northern Theater Command, Shenyang, 110000, China. 2482502448@qq.com.
³ Burn and Plastic Surgery Department, General Hospital of Northern Theater Command, Shenyang, 110000, China. luzongzhengxing@sina.com.

PMID: 38446322
DOI: 10.1007/s10528-024-10759-9

Abstract

Successful wound healing in diabetic patients is hindered by dysregulated miRNA expression. This study aimed to investigate the abnormal expression of miRNAs in diabetic wound healing and the potential therapeutic role of modulating the miR-206/HIF-1α pathway. MicroRNA assays were used to identify differentially expressed miRNAs in diabetic wound sites and adjacent areas. In vitro models and a rat diabetic model were established to evaluate the effects of miR-206 on HIF-1α regulation and wound healing. The study revealed differential expression of miR-206 in diabetic wound tissues, its interaction with HIF-1α, and the inhibitory effect of miR-206 on cell growth under high glucose conditions. Modulating the miR-206/HIF-1α pathway using miR-206 antagomir promoted HIF-1α, CD34, and VEGF expression, ultimately enhancing diabetic wound healing.

Keywords: Diabetic wounds; HIF-1α; Hyperglycemia; VEGF; miR-206.