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Analytical method validation for biomarkers as a drug development tool: points to consider.
Ohtsu Y, Tanaka S, Igarashi H, Kakehi M, Mori T, Nakamura T, Ohashi R, Shimizu H, Yasuda Y, Okayama T, Kakuo H, Yokoi H, Horiuchi M, Katashima M, Nakamura R, Saito K, Saito Y. Ohtsu Y, et al. Among authors: ohashi r. Bioanalysis. 2021 Sep;13(18):1379-1389. doi: 10.4155/bio-2021-0173. Epub 2021 Sep 14. Bioanalysis. 2021. PMID: 34517750 Free article.
An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
Hosogi J, Ohashi R, Maeda H, Fujita K, Ushiki J, Kuwabara T, Yamamoto Y, Imamura T. Hosogi J, et al. Among authors: ohashi r. Biopharm Drug Dispos. 2018 Mar;39(3):164-174. doi: 10.1002/bdd.2123. Biopharm Drug Dispos. 2018. PMID: 29451686
Determination of the anticancer drug KW-2170, a pyrazoloacridone derivative, and its metabolites in human and dog plasma by high-performance liquid chromatography using an electrochemical detector.
Kuramitsu T, Takai K, Ohashi R, Kuwabara T. Kuramitsu T, et al. Among authors: ohashi r. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 5;768(2):231-7. doi: 10.1016/s1570-0232(01)00580-3. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 11888050