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Page 1
Analytical method validation for biomarkers as a drug development tool: points to consider.
Bioanalysis. 2021 Sep;13(18):1379-1389. doi: 10.4155/bio-2021-0173. Epub 2021 Sep 14.
Bioanalysis. 2021.
PMID: 34517750
Free article.
An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
Hosogi J, Ohashi R, Maeda H, Fujita K, Ushiki J, Kuwabara T, Yamamoto Y, Imamura T.
Hosogi J, et al. Among authors: ohashi r.
Biopharm Drug Dispos. 2018 Mar;39(3):164-174. doi: 10.1002/bdd.2123.
Biopharm Drug Dispos. 2018.
PMID: 29451686
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Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential.
Tanaka R, Rubio A, Harn NK, Gernert D, Grese TA, Eishima J, Hara M, Yoda N, Ohashi R, Kuwabara T, Soga S, Akinaga S, Nara S, Kanda Y.
Tanaka R, et al. Among authors: ohashi r.
Bioorg Med Chem. 2007 Feb 1;15(3):1363-82. doi: 10.1016/j.bmc.2006.11.007. Epub 2006 Nov 9.
Bioorg Med Chem. 2007.
PMID: 17127066
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Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
Hosogi J, Ohashi R, Maeda H, Tashiro S, Fuse E, Yamamoto Y, Kuwabara T.
Hosogi J, et al. Among authors: ohashi r.
Drug Metab Pharmacokinet. 2017 Oct;32(5):255-264. doi: 10.1016/j.dmpk.2017.06.002. Epub 2017 Jun 22.
Drug Metab Pharmacokinet. 2017.
PMID: 28751116
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Determination of the anticancer drug KW-2170, a pyrazoloacridone derivative, and its metabolites in human and dog plasma by high-performance liquid chromatography using an electrochemical detector.
Kuramitsu T, Takai K, Ohashi R, Kuwabara T.
Kuramitsu T, et al. Among authors: ohashi r.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 5;768(2):231-7. doi: 10.1016/s1570-0232(01)00580-3.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002.
PMID: 11888050
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PARAFAC Decomposition for Ultrasonic Wave Sensing of Fiber Bragg Grating Sensors: Procedure and Evaluation.
Zheng R, Nakano K, Ohashi R, Okabe Y, Shimazaki M, Nakamura H, Wu Q.
Zheng R, et al. Among authors: ohashi r.
Sensors (Basel). 2015 Jul 7;15(7):16388-411. doi: 10.3390/s150716388.
Sensors (Basel). 2015.
PMID: 26198232
Free PMC article.
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