The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
Al-Samkari H, Addonizio K, Glader B, Morton DH, Chonat S, Thompson AA, Kuo KHM, Ravindranath Y, Wang H, Rothman JA, Kwiatkowski JL, Kung C, Kosinski PA, Al-Sayegh H, London WB, Grace RF.
Al-Samkari H, et al.
Br J Haematol. 2021 Mar;192(6):1092-1096. doi: 10.1111/bjh.16724. Epub 2020 May 28.
Br J Haematol. 2021.
PMID: 32463523
Free article.
Clinical Trial.
Transfusion requirements correlated with normalised erythrocyte ATP levels (r = 0.527, P = 0.0016) and PK-R protein levels (r = -0.527, P = 0.0028). PK-R protein levels were significantly higher in the never transfused [median (range) 40.1 (9.8-73.9)%] …
Transfusion requirements correlated with normalised erythrocyte ATP levels (r = 0.527, P = 0.0016) and PK-R protein levels ( …