Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1986 1
1988 1
1990 1
1993 3
1996 4
1997 3
1998 6
1999 8
2000 7
2001 5
2002 11
2003 20
2004 7
2005 14
2006 13
2007 21
2008 17
2009 23
2010 24
2011 21
2012 21
2013 51
2014 47
2015 42
2016 26
2017 18
2018 31
2019 28
2020 32
2021 42
2022 43
2023 41
2024 14

Text availability

Article attribute

Article type

Publication date

Search Results

570 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for non scap
Your search for Ron Scapp retrieved no results
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia.
Martin-Loeches I, Torres A, Nagavci B, Aliberti S, Antonelli M, Bassetti M, Bos LD, Chalmers JD, Derde L, de Waele J, Garnacho-Montero J, Kollef M, Luna CM, Menendez R, Niederman MS, Ponomarev D, Restrepo MI, Rigau D, Schultz MJ, Weiss E, Welte T, Wunderink R. Martin-Loeches I, et al. Intensive Care Med. 2023 Jun;49(6):615-632. doi: 10.1007/s00134-023-07033-8. Epub 2023 Apr 4. Intensive Care Med. 2023. PMID: 37012484 Free PMC article.
PURPOSE: Severe community-acquired pneumonia (sCAP) is associated with high morbidity and mortality, and whilst European and non-European guidelines are available for community-acquired pneumonia, there are no specific guidelines for sCAP. METHODS: The Europe …
PURPOSE: Severe community-acquired pneumonia (sCAP) is associated with high morbidity and mortality, and whilst European and non …
Retrospective on Cholesterol Homeostasis: The Central Role of Scap.
Brown MS, Radhakrishnan A, Goldstein JL. Brown MS, et al. Annu Rev Biochem. 2018 Jun 20;87:783-807. doi: 10.1146/annurev-biochem-062917-011852. Epub 2017 Aug 25. Annu Rev Biochem. 2018. PMID: 28841344 Free PMC article. Review.
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. ...When cholesterol in ER membranes exceeds a threshold, the sterol binds to Scap, triggering several conformational change …
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammali …
Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H. Kawamura S, et al. J Clin Invest. 2022 Jun 1;132(11):e151895. doi: 10.1172/JCI151895. J Clin Invest. 2022. PMID: 35380992 Free PMC article.
Unexpectedly, SREBP inhibition via deletion of the SREBP cleavage-activating protein (SCAP) in the liver exacerbated liver injury, fibrosis, and carcinogenesis despite markedly reduced hepatic steatosis. ...Supplementation with phosphatidylcholines significantly improved l …
Unexpectedly, SREBP inhibition via deletion of the SREBP cleavage-activating protein (SCAP) in the liver exacerbated liver injury, fi …
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Guo C, Chi Z, Jiang D, Xu T, Yu W, Wang Z, Chen S, Zhang L, Liu Q, Guo X, Zhang X, Li W, Lu L, Wu Y, Song BL, Wang D. Guo C, et al. Immunity. 2018 Nov 20;49(5):842-856.e7. doi: 10.1016/j.immuni.2018.08.021. Epub 2018 Oct 23. Immunity. 2018. PMID: 30366764 Free article.
However, this regulation did not predominantly depend on changes in cholesterol homeostasis controlled by the transcriptional activity of SREBP2, but relied on the escort activity of SCAP. Mechanistically, NLRP3 associated with SCAP-SREBP2 to form a ternary complex …
However, this regulation did not predominantly depend on changes in cholesterol homeostasis controlled by the transcriptional activity of SR …
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia.
Martin-Loeches I, Torres A, Nagavci B, Aliberti S, Antonelli M, Bassetti M, Bos L, Chalmers JD, Derde L, de Waele J, Garnacho-Montero J, Kollef M, Luna C, Menendez R, Niederman M, Ponomarev D, Restrepo M, Rigau D, Schultz MJ, Weiss E, Welte T, Wunderink R. Martin-Loeches I, et al. Eur Respir J. 2023 Apr 3;61(4):2200735. doi: 10.1183/13993003.00735-2022. Print 2023 Apr. Eur Respir J. 2023. PMID: 37012080
BACKGROUND: Severe community-acquired pneumonia (sCAP) is associated with high morbidity and mortality, and while European and non-European guidelines are available for community-acquired pneumonia, there are no specific guidelines for sCAP. MATERIALS AND MET …
BACKGROUND: Severe community-acquired pneumonia (sCAP) is associated with high morbidity and mortality, and while European and non …
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-kappaB Signaling Pathway.
Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y. Huang X, et al. Cell Mol Gastroenterol Hepatol. 2022;14(1):1-26. doi: 10.1016/j.jcmgh.2022.03.006. Epub 2022 Mar 31. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35367665 Free PMC article.
METHODS: C57BL/6J wild-type and macrophage SCAP-specific knockout mice (SCAP(deltaM)) were subjected to Paigen diet (PD) feeding induced lean NAFLD. ...Inhibition of macrophage SCAP may represent a new therapeutic strategy for the treatment of lean NAFLD....
METHODS: C57BL/6J wild-type and macrophage SCAP-specific knockout mice (SCAP(deltaM)) were subjected to Paigen diet (PD) feedi …
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X. Zheng ZG, et al. Autophagy. 2021 Jul;17(7):1592-1613. doi: 10.1080/15548627.2020.1757955. Epub 2020 May 20. Autophagy. 2021. PMID: 32432943 Free PMC article.
Mechanistically, lycorine promotes SCAP lysosomal degradation in a macroautophagy/autophagy-independent pathway, a mechanism completely distinct from current SCAP inhibitors. Furthermore, we determined that SQSTM1 captured SCAP after its exit from the ER. The …
Mechanistically, lycorine promotes SCAP lysosomal degradation in a macroautophagy/autophagy-independent pathway, a mechanism complete …
Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study.
Liu YN, Zhang YF, Xu Q, Qiu Y, Lu QB, Wang T, Zhang XA, Lin SH, Lv CL, Jiang BG, Li H, Li ZJ, Gao GF, Yang WZ, Hay SI, Wang LP, Fang LQ, Liu W; Chinese Center for Disease Control and Prevention Etiology Surveillance Study Team of Acute Respiratory Infections. Liu YN, et al. Lancet Microbe. 2023 May;4(5):e330-e339. doi: 10.1016/S2666-5247(23)00031-9. Epub 2023 Mar 28. Lancet Microbe. 2023. PMID: 37001538 Free article.
FINDINGS: Between January, 2009, and December, 2020, 18 807 patients with CAP (3771 [20.05%] with SCAP) were enrolled. For both children (aged 5 years) and older adults (aged >60 years), a higher overall rate of viral and bacterial infections, as well as viral-bacterial …
FINDINGS: Between January, 2009, and December, 2020, 18 807 patients with CAP (3771 [20.05%] with SCAP) were enrolled. For both child …
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.
Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W, Chakravarti A, Cheng X, Guo D. Cheng C, et al. Nat Metab. 2022 May;4(5):575-588. doi: 10.1038/s42255-022-00568-y. Epub 2022 May 9. Nat Metab. 2022. PMID: 35534729 Free PMC article.
Notably, 25-hydroxycholesterol blocks ammonia to access its binding site on SCAP. Mutating aspartate D428 to alanine prevents ammonia binding to SCAP, abolishes SREBP-1 activation and suppresses tumour growth. Our study characterizes the unknown role, opposite to st …
Notably, 25-hydroxycholesterol blocks ammonia to access its binding site on SCAP. Mutating aspartate D428 to alanine prevents ammonia …
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.
Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, Cheng X, Euthine V, Hu P, Guo JY, Lefai E, Kaur B, Nohturfft A, Ma J, Chakravarti A, Guo D. Cheng C, et al. Cancer Cell. 2015 Nov 9;28(5):569-581. doi: 10.1016/j.ccell.2015.09.021. Cancer Cell. 2015. PMID: 26555173 Free PMC article.
Glycosylation stabilizes SCAP and reduces its association with Insig-1, allowing movement of SCAP/SREBP to the Golgi and consequent proteolytic activation of SREBP. Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven gliobl …
Glycosylation stabilizes SCAP and reduces its association with Insig-1, allowing movement of SCAP/SREBP to the Golgi and conse …
570 results