Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1- c][1,2,4]Triazin-4-ols

Roman A Drokin; Dmitrii V Tiufiakov; Egor K Voinkov; Pavel A Slepukhin; Evgeny N Ulomsky; Yana L Esaulkova; Alexandrina S Volobueva; Kristina S Lantseva; Mariya A Misyurina; Vladimir V Zarubaev; Vladimir L Rusinov

doi:10.1007/s10593-021-02926-2

Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1- c][1,2,4]Triazin-4-ols

Chem Heterocycl Compd (N Y). 2021;57(4):473-478. doi: 10.1007/s10593-021-02926-2. Epub 2021 May 12.

Affiliations

¹ Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002 Russia.
² Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St, Yekaterinburg, 620108 Russia.
³ Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St, Saint Petersburg, 197101 Russia.
⁴ Saint Petersburg State University, 7/9 University Embankment, Saint Petersburg, 199034 Russia.

Abstract

An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Supplementary information: The online version contains supplementary material available at 10.1007/s10593-021-02926-2.

Keywords: 3-nitroazolo[5,1-с][1,2,4]triazines; Coxsackie B3 virus; antiviral activity; influenza virus; triazines; α-nitro ketones.