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Page 1
Showing results for domain can brussel
Search for Romain Van Brussel instead (1 results)
Nanobodies: natural single-domain antibodies.
Muyldermans S. Muyldermans S. Annu Rev Biochem. 2013;82:775-97. doi: 10.1146/annurev-biochem-063011-092449. Epub 2013 Mar 13. Annu Rev Biochem. 2013. PMID: 23495938 Review.
The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains. HCAbs fail to incorporate light (L) chains owing to the deletion of the first constant domain and a reshaped surface at the VHH side, which …
The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains. HCAbs f …
Protein Phase Separation: A New Phase in Cell Biology.
Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Boeynaems S, et al. Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27. Trends Cell Biol. 2018. PMID: 29602697 Free PMC article. Review.
There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, for …
There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies …
Theranostics in immuno-oncology using nanobody derivatives.
Lecocq Q, De Vlaeminck Y, Hanssens H, D'Huyvetter M, Raes G, Goyvaerts C, Keyaerts M, Devoogdt N, Breckpot K. Lecocq Q, et al. Theranostics. 2019 Oct 15;9(25):7772-7791. doi: 10.7150/thno.34941. eCollection 2019. Theranostics. 2019. PMID: 31695800 Free PMC article. Review.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN. Verstraete K, et al. Nat Commun. 2017 Apr 3;8:14937. doi: 10.1038/ncomms14937. Nat Commun. 2017. PMID: 28368013 Free PMC article.
We further show that the monoclonal antibody Tezepelumab partly exploits these principles to neutralize TSLP activity. Finally, we introduce a fusion protein comprising a tandem of the TSLPR and IL-7Ralpha extracellular domains, which harnesses the mechanistic intri …
We further show that the monoclonal antibody Tezepelumab partly exploits these principles to neutralize TSLP activity. Finally, we introduce …
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
Vincke C, Loris R, Saerens D, Martinez-Rodriguez S, Muyldermans S, Conrath K. Vincke C, et al. J Biol Chem. 2009 Jan 30;284(5):3273-3284. doi: 10.1074/jbc.M806889200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19010777 Free article.
Nanobodies, single-domain antigen-binding fragments of camelid-specific heavy-chain only antibodies offer special advantages in therapy over classic antibody fragments because of their smaller size, robustness, and preference to target unique epitopes. A Nanobody differs f …
Nanobodies, single-domain antigen-binding fragments of camelid-specific heavy-chain only antibodies offer special advantages in thera …
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma.
Keyaerts M, Xavier C, Heemskerk J, Devoogdt N, Everaert H, Ackaert C, Vanhoeij M, Duhoux FP, Gevaert T, Simon P, Schallier D, Fontaine C, Vaneycken I, Vanhove C, De Greve J, Lamote J, Caveliers V, Lahoutte T. Keyaerts M, et al. J Nucl Med. 2016 Jan;57(1):27-33. doi: 10.2967/jnumed.115.162024. Epub 2015 Oct 8. J Nucl Med. 2016. PMID: 26449837 Free article. Clinical Trial.
NMR-guided directed evolution.
Bhattacharya S, Margheritis EG, Takahashi K, Kulesha A, D'Souza A, Kim I, Yoon JH, Tame JRH, Volkov AN, Makhlynets OV, Korendovych IV. Bhattacharya S, et al. Nature. 2022 Oct;610(7931):389-393. doi: 10.1038/s41586-022-05278-9. Epub 2022 Oct 5. Nature. 2022. PMID: 36198791 Free PMC article.
Nonetheless, its potential in even small proteins is inherently limited by the astronomical number of possible amino acid sequences. Sampling the complete sequence space of a 100-residue protein would require testing of 20(100) combinations, which is beyond any existing ex …
Nonetheless, its potential in even small proteins is inherently limited by the astronomical number of possible amino acid sequences. Samplin …
Targeting protein self-association in drug design.
Thabault L, Liberelle M, Frédérick R. Thabault L, et al. Drug Discov Today. 2021 May;26(5):1148-1163. doi: 10.1016/j.drudis.2021.01.028. Epub 2021 Feb 3. Drug Discov Today. 2021. PMID: 33548462 Review.
Protein self-association is a universal phenomenon essential for stability and molecular recognition. ...Targeting self-interaction grants several advantages over active site inhibition because of the stimulation of protein degradation, the enhancement of selectivit …
Protein self-association is a universal phenomenon essential for stability and molecular recognition. ...Targeting self-interaction g …
Orally delivered single-domain antibodies against gastrointestinal pathogens.
Petersson M, Thrane SW, Gram L, Muyldermans S, Laustsen AH. Petersson M, et al. Trends Biotechnol. 2023 Jul;41(7):875-886. doi: 10.1016/j.tibtech.2023.01.015. Epub 2023 Feb 9. Trends Biotechnol. 2023. PMID: 36774206 Free article. Review.
Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the antigen-binding domains of immunoglobulins. They can withstand extreme pH, high temperature, and proteolysis, making them suitable for controlling gastrointestinal (GI) infections i …
Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the antigen-binding domains of immunoglobulin …
Nanobodies to study protein conformational states.
Uchański T, Pardon E, Steyaert J. Uchański T, et al. Curr Opin Struct Biol. 2020 Feb;60:117-123. doi: 10.1016/j.sbi.2020.01.003. Epub 2020 Feb 6. Curr Opin Struct Biol. 2020. PMID: 32036243 Review.
2,646 results