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Page 1
Small Molecule Drug Discovery for Neglected Tropical Snakebite.
Trends Pharmacol Sci. 2021 May;42(5):340-353. doi: 10.1016/j.tips.2021.02.005. Epub 2021 Mar 24.
Trends Pharmacol Sci. 2021.
PMID: 33773806
Review.
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.
Khalek IS, Senji Laxme RR, Nguyen YTK, Khochare S, Patel RN, Woehl J, Smith JM, Saye-Francisco K, Kim Y, Misson Mindrebo L, Tran Q, Kędzior M, Boré E, Limbo O, Verma M, Stanfield RL, Menzies SK, Ainsworth S, Harrison RA, Burton DR, Sok D, Wilson IA, Casewell NR, Sunagar K, Jardine JG.
Khalek IS, et al. Among authors: patel rn.
Sci Transl Med. 2024 Feb 21;16(735):eadk1867. doi: 10.1126/scitranslmed.adk1867. Epub 2024 Feb 21.
Sci Transl Med. 2024.
PMID: 38381847
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Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL.
Laprade W, Bartlett KE, Christensen CR, Kazandjian TD, Patel RN, Crittenden E, Dawson CA, Mansourvar M, Wolff DS, Fryer T, Laustsen AH, Casewell NR, Gutiérrez JM, Hall SR, Jenkins TP.
Laprade W, et al. Among authors: patel rn.
Sci Rep. 2023 Dec 8;13(1):21662. doi: 10.1038/s41598-023-49011-6.
Sci Rep. 2023.
PMID: 38066189
Free PMC article.
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(-)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors.
Richards DP, Patel RN, Duce IR, Khambay BPS, Birkett MA, Pickett JA, Mellor IR.
Richards DP, et al. Among authors: patel rn.
Molecules. 2022 Oct 20;27(20):7074. doi: 10.3390/molecules27207074.
Molecules. 2022.
PMID: 36296666
Free PMC article.
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Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition.
Kachel HS, Patel RN, Franzyk H, Mellor IR.
Kachel HS, et al. Among authors: patel rn.
Sci Rep. 2016 Nov 30;6:38116. doi: 10.1038/srep38116.
Sci Rep. 2016.
PMID: 27901080
Free PMC article.
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An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.
Patel RN, Clare RH, Ledsgaard L, Nys M, Kool J, Laustsen AH, Ulens C, Casewell NR.
Patel RN, et al.
Biochem Pharmacol. 2023 Oct;216:115758. doi: 10.1016/j.bcp.2023.115758. Epub 2023 Aug 20.
Biochem Pharmacol. 2023.
PMID: 37604290
Free PMC article.
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Actions on mammalian and insect nicotinic acetylcholine receptors of harmonine-containing alkaloid extracts from the harlequin ladybird Harmonia axyridis.
Patel RN, Richards DP, Duce IR, Birkett MA, Sattelle DB, Mellor IR.
Patel RN, et al.
Pestic Biochem Physiol. 2020 Jun;166:104561. doi: 10.1016/j.pestbp.2020.104561. Epub 2020 Mar 6.
Pestic Biochem Physiol. 2020.
PMID: 32448416
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