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PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia.
Macente J, Nauwelaerts N, Russo FM, Deprest J, Allegaert K, Lammens B, Hernandes Bonan R, Turner JM, Kumar S, Diniz A, Martins FS, Annaert P. Macente J, et al. Among authors: hernandes bonan r. Front Pharmacol. 2023 Mar 14;14:1068153. doi: 10.3389/fphar.2023.1068153. eCollection 2023. Front Pharmacol. 2023. PMID: 36998614 Free PMC article.
Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling-A Contribution from the ConcePTION Project.
Nauwelaerts N, Macente J, Deferm N, Bonan RH, Huang MC, Van Neste M, Bibi D, Badee J, Martins FS, Smits A, Allegaert K, Bouillon T, Annaert P. Nauwelaerts N, et al. Among authors: bonan rh. Pharmaceutics. 2023 May 11;15(5):1469. doi: 10.3390/pharmaceutics15051469. Pharmaceutics. 2023. PMID: 37242712 Free PMC article.
Adult and pediatric physiologically-based biopharmaceutics modeling to explain lamotrigine immediate release absorption process.
Caleffi-Marchesini ER, Herling AA, Macente J, Bonan RH, de Freitas Lima P, Moreno R, Alexandre V, Charbe NB, Borghi-Pangoni FB, Cristofoletti R, Diniz A. Caleffi-Marchesini ER, et al. Among authors: bonan rh. CPT Pharmacometrics Syst Pharmacol. 2024 Feb;13(2):208-221. doi: 10.1002/psp4.13071. Epub 2023 Nov 14. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 37916262 Free PMC article.