Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines

Robert I Haines; Aleisha M Murnaghan

doi:10.1155/MBD.2002.61

Facile Synthesis of cis-Dichloro-(1,4,7-Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK-OV-3) and Leukemia (K-562) Cell Lines

Met Based Drugs. 2002;9(1-2):61-7. doi: 10.1155/MBD.2002.61.

Authors

Robert I Haines¹, Aleisha M Murnaghan

Affiliation

¹ Department of Chemistry University of Prince Edward Island 550 University Avenue Charlottetown PE CIA 4P3 Canada.

Abstract

A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl(2) is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562 cells, there is evidence for some cytotoxicity against SK-OV-3. The compound is much less effective than cisplatin, and its limited solubility restricts the useable concentration range.