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Hofland J, Ouattara A, Schaller M, Bein B, de Liefde I, Fellahi JL, Gruenewald M, Hazebroucq J, Ecoffey C, Joseph P, Heringlake M, Steib A, Coburn M, Amour J, Rozec B, Meybohm P, Preckel B, Hanouz JL, Tritapepe L, Tonner P, Benhaoua H, Roesner JP, Tenbrinck R, Bogers AJ, Mik BG, Coiffic A, Renner J, Steinfath M, Francksen H, Broch O, Haneya A, Guinet P, Daviet L, Brianchon C, Rosier S, Lehot JJ, Paarmann H, Schön J, Hanke T, Ettel J, Olsson S, Klotz S, Samet A, Laurinenas G, Thibaud A, Cristinar M, Collanges O, Levy F, Rossaint R, Stevanovic A, Schaelte G, Stoppe C, Hamou NA, Hariri S, Quessard A, Carillion A, Morin H, Silleran J, Robert D, Crouzet AS, Zacharowski K, Reyher C, Iken S, Weber NC, Hollmann M, Eberl S, Carriero G, Collacchi D, Di Persio A, Fourcade O, Bergt S, Alms A; Xenon-CABG Study Group. Hofland J, et al. Anesthesiology. 2018 Sep;129(3):611-613. doi: 10.1097/ALN.0000000000002317. Anesthesiology. 2018. PMID: 30106784 Free article. No abstract available.
Long-term use of ticagrelor in patients with prior myocardial infarction.
Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Bonaca MP, et al. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14. N Engl J Med. 2015. PMID: 25773268 Free article. Clinical Trial.
We investigated the efficacy and safety of ticagrelor, a P2Y12 receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS: We randomly assigned, in a double-blind 1:1:1 fashion, 21,162 patients who had had a myocardial infarcti …
We investigated the efficacy and safety of ticagrelor, a P2Y12 receptor antagonist with established efficacy after an acute coronary synd …
Bardet-Biedl syndrome: Weight patterns and genetics in a rare obesity syndrome.
Pomeroy J, Krentz AD, Richardson JG, Berg RL, VanWormer JJ, Haws RM. Pomeroy J, et al. Pediatr Obes. 2021 Feb;16(2):e12703. doi: 10.1111/ijpo.12703. Epub 2020 Jul 22. Pediatr Obes. 2021. PMID: 32700463 Free PMC article.
BACKGROUND: Bardet-Biedl syndrome (BBS) is a rare genetic disorder that severely inhibits primary cilia function. ...
BACKGROUND: Bardet-Biedl syndrome (BBS) is a rare genetic disorder that severely inhibits primary cilia function. ...
Sleep and physical activity patterns in adults and children with Bardet-Biedl syndrome.
Pomeroy J, VanWormer JJ, Meilahn JR, Maki T, Murali HR, Haws RM. Pomeroy J, et al. Orphanet J Rare Dis. 2021 Jun 14;16(1):276. doi: 10.1186/s13023-021-01911-4. Orphanet J Rare Dis. 2021. PMID: 34127036 Free PMC article.
BACKGROUND: Overweight and obesity are common features of the rare disease Bardet-Biedl syndrome (BBS). Sleep and physical activity are behaviors that might impact overweight and obesity and thus may play a key role in the health and well-being of people with BBS. ...
BACKGROUND: Overweight and obesity are common features of the rare disease Bardet-Biedl syndrome (BBS). Sleep and physical activity a …
Optimising Exome Prenatal Sequencing Services (EXPRESS): a study protocol to evaluate rapid prenatal exome sequencing in the NHS Genomic Medicine Service.
Hill M, Ellard S, Fisher J, Fulop N, Knight M, Kroese M, Ledger J, Leeson-Beevers K, McEwan A, McMullan D, Mellis R, Morris S, Parker M, Tapon D, Baple E, Blackburn L, Choudry A, Lafarge C, McInnes-Dean H, Peter M, Ramakrishnan R, Roberts L, Searle B, Smith E, Walton H, Wynn SL, Han Wu W, Chitty LS. Hill M, et al. NIHR Open Res. 2022 Jul 18;2:10. doi: 10.3310/nihropenres.13247.2. eCollection 2022. NIHR Open Res. 2022. PMID: 35935673 Free PMC article.
'Something that helped the whole picture': Experiences of parents offered rapid prenatal exome sequencing in routine clinical care in the English National Health Service.
McInnes-Dean H, Mellis R, Daniel M, Walton H, Baple EL, Bertoli M, Fisher J, Gajewska-Knapik K, Holder-Espinasse M, Lafarge C, Leeson-Beevers K, McEwan A, Pandya P, Parker M, Peet S, Roberts L, Sankaran S, Smith A, Tapon D, Wu WH, Wynn SL, Chitty LS, Hill M, Peter M. McInnes-Dean H, et al. Prenat Diagn. 2024 Apr;44(4):465-479. doi: 10.1002/pd.6537. Epub 2024 Mar 5. Prenat Diagn. 2024. PMID: 38441167
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alstrom syndrome.
McKay EJ, Luijten I, Weng X, Martinez de Morentin PB, De Frutos González E, Gao Z, Kolonin MG, Heisler LK, Semple RK. McKay EJ, et al. Mol Metab. 2024 Apr 6;84:101933. doi: 10.1016/j.molmet.2024.101933. Online ahead of print. Mol Metab. 2024. PMID: 38583571 Free PMC article.
OBJECTIVE: Alstrom Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. ...
OBJECTIVE: Alstrom Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin …
The ice age with little effect? Exploring stress in the Danish Black Friars cemetery before and after the turn of the 14th century.
Scott AB, Hoppa RD. Scott AB, et al. Int J Paleopathol. 2019 Sep;26:157-163. doi: 10.1016/j.ijpp.2018.12.004. Epub 2018 Dec 27. Int J Paleopathol. 2019. PMID: 30595482
It was expected that increased stress would be evident in those buried after the turn of the 14th century due to the many challenges associated with wide spread climatic cooling; however, the reliance on nutrient rich marine resources and alms provisions may have helped le …
It was expected that increased stress would be evident in those buried after the turn of the 14th century due to the many challenges associa …
Effect of Xenon Anesthesia Compared to Sevoflurane and Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery on Postoperative Cardiac Troponin Release: An International, Multicenter, Phase 3, Single-blinded, Randomized Noninferiority Trial.
Hofland J, Ouattara A, Fellahi JL, Gruenewald M, Hazebroucq J, Ecoffey C, Joseph P, Heringlake M, Steib A, Coburn M, Amour J, Rozec B, Liefde I, Meybohm P, Preckel B, Hanouz JL, Tritapepe L, Tonner P, Benhaoua H, Roesner JP, Bein B, Hanouz L, Tenbrinck R, Bogers AJJC, Mik BG, Coiffic A, Renner J, Steinfath M, Francksen H, Broch O, Haneya A, Schaller M, Guinet P, Daviet L, Brianchon C, Rosier S, Lehot JJ, Paarmann H, Schön J, Hanke T, Ettel J, Olsson S, Klotz S, Samet A, Laurinenas G, Thibaud A, Cristinar M, Collanges O, Levy F, Rossaint R, Stevanovic A, Schaelte G, Stoppe C, Hamou NA, Hariri S, Quessard A, Carillion A, Morin H, Silleran J, Robert D, Crouzet AS, Zacharowski K, Reyher C, Iken S, Weber NC, Hollmann M, Eberl S, Carriero G, Collacchi D, Di Persio A, Fourcade O, Bergt S, Alms A; Xenon-CABG Study Group. Hofland J, et al. Anesthesiology. 2017 Dec;127(6):918-933. doi: 10.1097/ALN.0000000000001873. Anesthesiology. 2017. PMID: 28872484 Free article. Clinical Trial.