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Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN. Rosado-Ramos R, et al. Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2. Nat Commun. 2023. PMID: 37024503 Free PMC article.
Small Molecule Fisetin Modulates Alpha-Synuclein Aggregation.
Rosado-Ramos R, Godinho-Pereira J, Marques D, Figueira I, Fleming Outeiro T, Menezes R, Nunes Dos Santos C. Rosado-Ramos R, et al. Molecules. 2021 Jun 2;26(11):3353. doi: 10.3390/molecules26113353. Molecules. 2021. PMID: 34199487 Free PMC article.
Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease.
Kallscheuer N, Menezes R, Foito A, da Silva MH, Braga A, Dekker W, Sevillano DM, Rosado-Ramos R, Jardim C, Oliveira J, Ferreira P, Rocha I, Silva AR, Sousa M, Allwood JW, Bott M, Faria N, Stewart D, Ottens M, Naesby M, Nunes Dos Santos C, Marienhagen J. Kallscheuer N, et al. Among authors: rosado ramos r. Plant Physiol. 2019 Mar;179(3):969-985. doi: 10.1104/pp.18.01074. Epub 2018 Nov 5. Plant Physiol. 2019. PMID: 30397021 Free PMC article.
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.
Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF. Tenreiro S, et al. Among authors: rosado ramos r. PLoS Genet. 2014 May 8;10(5):e1004302. doi: 10.1371/journal.pgen.1004302. eCollection 2014 May. PLoS Genet. 2014. PMID: 24810576 Free PMC article.