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Development of hybrid immunity during a period of high incidence of Omicron infections.
Frei A, Kaufmann M, Amati R, Butty Dettwiler A, von Wyl V, Annoni AM, Vincentini J, Pellaton C, Pantaleo G, Fehr JS, D'Acremont V, Bochud M, Albanese E, Puhan MA; Corona Immunitas Research Group. Frei A, et al. Int J Epidemiol. 2023 Dec 25;52(6):1696-1707. doi: 10.1093/ije/dyad098. Int J Epidemiol. 2023. PMID: 37407273 Free PMC article.
Individuals with hybrid immunity had highest median levels of anti-spike IgG antibodies titres [4518 World Health Organization units per millilitre (WHO U/mL)] compared with those with only vaccine- (4304 WHO U/mL) or infection- (269 WHO U/mL) induced immunity, and highest …
Individuals with hybrid immunity had highest median levels of anti-spike IgG antibodies titres [4518 World Health Organization units …
Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.
Li T, Cai H, Zhao Y, Li Y, Lai Y, Yao H, Liu LD, Sun Z, van Vlissingen MF, Kuiken T, GeurtsvanKessel CH, Zhang N, Zhou B, Lu L, Gong Y, Qin W, Mondal M, Duan B, Xu S, Richard AS, Raoul H, Chen J, Xu C, Wu L, Zhou H, Huang Z, Zhang X, Li J, Wang Y, Bi Y, Rockx B, Chen J, Meng FL, Lavillette D, Li D. Li T, et al. Among authors: richard as. EMBO Mol Med. 2021 Dec 7;13(12):e14544. doi: 10.15252/emmm.202114544. Epub 2021 Nov 17. EMBO Mol Med. 2021. PMID: 34672091 Free PMC article.
An essential step for SARS-CoV-2 infection is the attachment to the host cell receptor by its Spike receptor-binding domain (RBD). Most of the existing RBD-targeting neutralizing antibodies block the receptor-binding motif (RBM), a mutable region with the potential to gene …
An essential step for SARS-CoV-2 infection is the attachment to the host cell receptor by its Spike receptor-binding domain (RBD). Mo …
Seroprevalence trends of anti-SARS-CoV-2 antibodies and associated risk factors: a population-based study.
Tancredi S, Chiolero A, Wagner C, Haller ML, Chocano-Bedoya P, Ortega N, Rodondi N, Kaufmann L, Lorthe E, Baysson H, Stringhini S, Michel G, Lüdi C, Harju E, Frank I, Imboden M, Witzig M, Keidel D, Probst-Hensch N, Amati R, Albanese E, Corna L, Crivelli L, Vincentini J, Gonseth Nusslé S, Bochud M, D'Acremont V, Kohler P, Kahlert CR, Cusini A, Frei A, Puhan MA, Geigges M, Kaufmann M, Fehr J, Cullati S; Corona Immunitas Research Group. Tancredi S, et al. Infection. 2023 Oct;51(5):1453-1465. doi: 10.1007/s15010-023-02011-0. Epub 2023 Mar 4. Infection. 2023. PMID: 36870034 Free PMC article.
We defined three study periods: May-October 2020 (period 1, prior to vaccination), November 2020-mid-May 2021 (period 2, first months of the vaccination campaign), and mid-May-September 2021 (period 3, a large share of the population vaccinated). We measured anti-spike IgG …
We defined three study periods: May-October 2020 (period 1, prior to vaccination), November 2020-mid-May 2021 (period 2, first months of the …
Selective serotonin reuptake inhibitor treatment retunes emotional valence in primate ventral striatum.
Pasquereau B, Drui G, Saga Y, Richard A, Millot M, Météreau E, Sgambato V, Tobler PN, Tremblay L. Pasquereau B, et al. Among authors: richard a. Neuropsychopharmacology. 2021 Nov;46(12):2073-2082. doi: 10.1038/s41386-021-00991-x. Epub 2021 Mar 10. Neuropsychopharmacology. 2021. PMID: 33692476 Free PMC article.
Here we ask whether and how the effectiveness of the SSRI fluoxetine is underpinned by neural mechanisms in the ventral striatum. To address these issues, we studied the spiking activity of neurons in the ventral striatum of monkeys during an approach-avoidance task in whi …
Here we ask whether and how the effectiveness of the SSRI fluoxetine is underpinned by neural mechanisms in the ventral striatum. To address …
An integrate-and-fire model to generate spike trains with long-range dependence.
Richard A, Orio P, Tanré E. Richard A, et al. J Comput Neurosci. 2018 Jun;44(3):297-312. doi: 10.1007/s10827-018-0680-1. Epub 2018 Mar 24. J Comput Neurosci. 2018. PMID: 29574632
Long-range dependence (LRD) has been observed in a variety of phenomena in nature, and for several years also in the spiking activity of neurons. Often, this is interpreted as originating from a non-Markovian system. ...For comparison, we also consider a new model of indiv …
Long-range dependence (LRD) has been observed in a variety of phenomena in nature, and for several years also in the spiking activity …
Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data.
Eling N, Richard AC, Richardson S, Marioni JC, Vallejos CA. Eling N, et al. Among authors: richard ac. Cell Syst. 2018 Sep 26;7(3):284-294.e12. doi: 10.1016/j.cels.2018.06.011. Epub 2018 Aug 29. Cell Syst. 2018. PMID: 30172840 Free PMC article.
This includes a robust procedure for quantifying technical noise in experiments where technical spike-in molecules are not available. We illustrate how our method provides biological insight into the dynamics of cell-to-cell expression variability, highlighting a synchroni …
This includes a robust procedure for quantifying technical noise in experiments where technical spike-in molecules are not available. …
ChAdOx1 nCoV-19 vaccination generates spike-specific CD8(+) T cells in aged mice.
Foster WS, Newman J, Thakur N, Spencer AJ, Davies S, Woods D, Godfrey L, Ross SH, Sharpe HJ, Richard AC, Bailey D, Lambe T, Linterman MA. Foster WS, et al. Among authors: richard ac. Immunol Cell Biol. 2023 Jul;101(6):479-488. doi: 10.1111/imcb.12645. Epub 2023 May 6. Immunol Cell Biol. 2023. PMID: 36975169 Free PMC article.
This is particularly important in cases where antibody titers are suboptimal, as can occur in older individuals. Here, we show that in aged mice, spike epitope-specific CD8(+) T cells are generated in comparable numbers to younger animals after ChAdOx1 nCoV-19 vaccination, …
This is particularly important in cases where antibody titers are suboptimal, as can occur in older individuals. Here, we show that in aged …
Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia.
Popa T, Hubsch C, James P, Richard A, Russo M, Pradeep S, Krishan S, Roze E, Meunier S, Kishore A. Popa T, et al. Among authors: richard a. Sci Rep. 2018 Feb 2;8(1):2263. doi: 10.1038/s41598-018-20510-1. Sci Rep. 2018. PMID: 29396401 Free PMC article.
The cerebellum can influence the responsiveness of the primary motor cortex (M1) to undergo spike timing-dependent plastic changes through a complex mechanism involving multiple relays in the cerebello-thalamo-cortical pathway. ...
The cerebellum can influence the responsiveness of the primary motor cortex (M1) to undergo spike timing-dependent plastic changes th …
Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation.
Richard AC, Lyons PA, Peters JE, Biasci D, Flint SM, Lee JC, McKinney EF, Siegel RM, Smith KG. Richard AC, et al. BMC Genomics. 2014 Aug 4;15(1):649. doi: 10.1186/1471-2164-15-649. BMC Genomics. 2014. PMID: 25091430 Free PMC article.
BACKGROUND: Although numerous investigations have compared gene expression microarray platforms, preprocessing methods and batch correction algorithms using constructed spike-in or dilution datasets, there remains a paucity of studies examining the properties of microarray …
BACKGROUND: Although numerous investigations have compared gene expression microarray platforms, preprocessing methods and batch correction …