Hypocholesterolemic effects of nutraceuticals produced from the red microalga Porphyridium sp in rats

Nutrients. 2009 Feb;1(2):156-67. doi: 10.3390/nu1020156. Epub 2009 Nov 23.

Abstract

Red microalgae contain functional sulfated polysaccharides (containing dietary fibers), polyunsaturated fatty acids, zeaxanthin, vitamins, minerals, and proteins. Studies in rat models support the therapeutic properties of algal biomass and isolated polysaccharides. Algal products incorporated into rat diets were found to significantly improve total serum cholesterol, serum triglycerides, hepatic cholesterol levels, HDL/LDL ratios and increased fecal excretion of neutral sterols and bile acids. Morphological and metabolic changes were induced by consumption of algal products. These results suggest that red microalgae can be used as potent hypocholesterolemic agents, and they support the potential use of red microalgae as novel nutraceuticals.

Keywords: dietary fiber; foodomics; hypocholesterolemic agents; nutraceuticals; red microalgae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed
  • Animals
  • Dietary Fiber / analysis
  • Dietary Fiber / pharmacology
  • Dietary Supplements / analysis*
  • Feces / chemistry
  • Hypercholesterolemia / drug therapy*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology*
  • Lipids / blood
  • Liver / chemistry
  • Male
  • Organ Size
  • Polysaccharides / chemistry
  • Polysaccharides / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Rhodophyta / chemistry*
  • Sterols / chemistry
  • Sterols / metabolism
  • Weight Gain

Substances

  • Dietary Fiber
  • Hypolipidemic Agents
  • Lipids
  • Polysaccharides
  • Sterols