An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO2

Renle Cui; Caihong Liu; Ping Zhang; Kun Qin; Yanqing Ge

doi:10.3390/molecules28020515

An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂

Molecules. 2023 Jan 5;28(2):515. doi: 10.3390/molecules28020515.

Authors

Renle Cui¹, Caihong Liu¹, Ping Zhang¹, Kun Qin¹, Yanqing Ge¹

Affiliation

¹ Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China.

Abstract

A mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO₂ in living SKOV-3 cells, zebrafish and living mice which may be useful for understanding the biological roles of SO₂ in mitochondria and in vivo.

Keywords: FRET; bioimaging; imidazo[1,2-a]pyridine; mitochondria; ultra-large Stokes shifts.

MeSH terms

Animals
Fluorescent Dyes*
HeLa Cells
Humans
Mice
Mitochondria
Pyridines
Zebrafish*

Substances

Fluorescent Dyes
Pyridines

Grants and funding

ZR2021MB033/The Natural Science Foundation of Shandong Province