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Page 1
A One-Pot Synthesis of Highly Functionalized Purines.
Zelli R, Zeinyeh W, Haudecoeur R, Alliot J, Boucherle B, Callebaut I, Décout JL. Zelli R, et al. Org Lett. 2017 Dec 1;19(23):6360-6363. doi: 10.1021/acs.orglett.7b03209. Epub 2017 Nov 10. Org Lett. 2017. PMID: 29125774
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Froux L, Elbahnsi A, Boucherle B, Billet A, Baatallah N, Hoffmann B, Alliot J, Zelli R, Zeinyeh W, Haudecoeur R, Chevalier B, Fortuné A, Mirval S, Simard C, Lehn P, Mornon JP, Hinzpeter A, Becq F, Callebaut I, Décout JL. Froux L, et al. Among authors: zelli r. Eur J Med Chem. 2020 Mar 15;190:112116. doi: 10.1016/j.ejmech.2020.112116. Epub 2020 Feb 9. Eur J Med Chem. 2020. PMID: 32078860
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Baatallah N, Elbahnsi A, Mornon JP, Chevalier B, Pranke I, Servel N, Zelli R, Décout JL, Edelman A, Sermet-Gaudelus I, Callebaut I, Hinzpeter A. Baatallah N, et al. Among authors: zelli r. Cell Mol Life Sci. 2021 Dec;78(23):7813-7829. doi: 10.1007/s00018-021-03994-5. Epub 2021 Oct 29. Cell Mol Life Sci. 2021. PMID: 34714360 Free article.