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Dual soluble epoxide hydrolase inhibitor/PPAR-γ agonist attenuates renal fibrosis.
Stavniichuk A, Hye Khan MA, Yeboah MM, Chesnik MA, Jankiewicz WK, Hartmann M, Blöcher R, Kircher T, Savchuk O, Proschak E, Imig JD. Stavniichuk A, et al. Among authors: blocher r. Prostaglandins Other Lipid Mediat. 2020 Oct;150:106472. doi: 10.1016/j.prostaglandins.2020.106472. Epub 2020 Jun 20. Prostaglandins Other Lipid Mediat. 2020. PMID: 32569747
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase.
Hiesinger K, Schott A, Kramer JS, Blöcher R, Witt F, Wittmann SK, Steinhilber D, Pogoryelov D, Gerstmeier J, Werz O, Proschak E. Hiesinger K, et al. Among authors: blocher r. ACS Med Chem Lett. 2019 Oct 30;11(3):298-302. doi: 10.1021/acsmedchemlett.9b00330. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184960 Free PMC article.
Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.
Lehmann C, Homann J, Ball AK, Blöcher R, Kleinschmidt TK, Basavarajappa D, Angioni C, Ferreirós N, Häfner AK, Rådmark O, Proschak E, Haeggström JZ, Geisslinger G, Parnham MJ, Steinhilber D, Kahnt AS. Lehmann C, et al. Among authors: blocher r. FASEB J. 2015 Dec;29(12):5029-43. doi: 10.1096/fj.15-275487. Epub 2015 Aug 19. FASEB J. 2015. PMID: 26289316
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ. Roos J, et al. Among authors: blocher r. Antioxid Redox Signal. 2018 May 10;28(14):1265-1285. doi: 10.1089/ars.2017.7155. Epub 2017 Sep 8. Antioxid Redox Signal. 2018. PMID: 28699354
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.
Blöcher R, Lamers C, Wittmann SK, Merk D, Hartmann M, Weizel L, Diehl O, Brüggerhoff A, Boß M, Kaiser A, Schader T, Göbel T, Grundmann M, Angioni C, Heering J, Geisslinger G, Wurglics M, Kostenis E, Brüne B, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E. Blöcher R, et al. J Med Chem. 2016 Jan 14;59(1):61-81. doi: 10.1021/acs.jmedchem.5b01239. Epub 2015 Dec 25. J Med Chem. 2016. PMID: 26595749
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