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Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Guzman MA, Rugel A, Alwan SN, Tarpley R, Taylor AB, Chevalier FD, Wendt GR, Collins JJ 3rd, Anderson TJC, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: tarpley r. Pharmaceutics. 2022 Jul 6;14(7):1416. doi: 10.3390/pharmaceutics14071416. Pharmaceutics. 2022. PMID: 35890311 Free PMC article.
Molecular basis for hycanthone drug action in schistosome parasites.
Guzman M, Rugel A, Tarpley RS, Cao X, McHardy SF, LoVerde PT, Taylor AB. Guzman M, et al. Among authors: tarpley rs. Mol Biochem Parasitol. 2020 Mar;236:111257. doi: 10.1016/j.molbiopara.2020.111257. Epub 2020 Feb 3. Mol Biochem Parasitol. 2020. PMID: 32027942
Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel AR, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ, LoVerde PT. Rugel AR, et al. Among authors: tarpley rs. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:8-15. doi: 10.1016/j.ijpddr.2020.04.001. Epub 2020 Apr 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 32315953 Free PMC article.
Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
Taylor AB, Roberts KM, Cao X, Clark NE, Holloway SP, Donati E, Polcaro CM, Pica-Mattoccia L, Tarpley RS, McHardy SF, Cioli D, LoVerde PT, Fitzpatrick PF, Hart PJ. Taylor AB, et al. Among authors: tarpley rs. J Biol Chem. 2017 Jul 7;292(27):11154-11164. doi: 10.1074/jbc.M116.766527. Epub 2017 May 23. J Biol Chem. 2017. PMID: 28536265 Free PMC article.
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.
Guzman MA, Rugel AR, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy DP, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: tarpley rs. PLoS Negl Trop Dis. 2020 Aug 18;14(8):e0008517. doi: 10.1371/journal.pntd.0008517. eCollection 2020 Aug. PLoS Negl Trop Dis. 2020. PMID: 32810153 Free PMC article.