Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression.
Gamage HEV, Shahoei SH, Albright ST, Wang Y, Smith AJ, Farmer R, Fink EC, Jacquin E, Weisser E, Bautista RO, Henn MA, Schane CP, Nelczyk AT, Ma L, Gupta AD, Bendre SV, Nguyen T, Tiwari S, Krawczynska N, He S, Tjoanda E, Chen H, Sverdlov M, Gann PH, Boidot R, Vegran F, Fanning SW, Apetoh L, Hergenrother PJ, Nelson ER.
Gamage HEV, et al.
bioRxiv [Preprint]. 2023 Aug 14:2023.08.14.553229. doi: 10.1101/2023.08.14.553229.
bioRxiv. 2023.
PMID: 37645737
Free PMC article.
Preprint.
We demonstrate that NR0B2, a protein involved in cholesterol homeostasis, functions within myeloid immune cells to modulate the NLRP3 inflammasome and reduce the expansion of immune-suppressive regulatory T cells (T(reg)). Loss of NR0B2 increased mammary tumor growth and m …
We demonstrate that NR0B2, a protein involved in cholesterol homeostasis, functions within myeloid immune cells to modulate the NLRP3 inflam …