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Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease.
Marttinen M, Takalo M, Natunen T, Wittrahm R, Gabbouj S, Kemppainen S, Leinonen V, Tanila H, Haapasalo A, Hiltunen M. Marttinen M, et al. Among authors: wittrahm r. Front Neurosci. 2018 Dec 14;12:963. doi: 10.3389/fnins.2018.00963. eCollection 2018. Front Neurosci. 2018. PMID: 30618585 Free PMC article. Review.
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models.
Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M. Wittrahm R, et al. Neurobiol Dis. 2023 Jun 15;182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. Neurobiol Dis. 2023. PMID: 37120095 Free article.
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.
Takalo M, Wittrahm R, Wefers B, Parhizkar S, Jokivarsi K, Kuulasmaa T, Mäkinen P, Martiskainen H, Wurst W, Xiang X, Marttinen M, Poutiainen P, Haapasalo A, Hiltunen M, Haass C. Takalo M, et al. Among authors: wittrahm r. Mol Neurodegener. 2020 Sep 11;15(1):52. doi: 10.1186/s13024-020-00402-7. Mol Neurodegener. 2020. PMID: 32917267 Free PMC article.
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.
Gabbouj S, Natunen T, Koivisto H, Jokivarsi K, Takalo M, Marttinen M, Wittrahm R, Kemppainen S, Naderi R, Posado-Fernández A, Ryhänen S, Mäkinen P, Paldanius KMA, Doria G, Poutiainen P, Flores O, Haapasalo A, Tanila H, Hiltunen M. Gabbouj S, et al. Among authors: wittrahm r. Neurobiol Aging. 2019 Mar;75:98-108. doi: 10.1016/j.neurobiolaging.2018.11.008. Epub 2018 Nov 17. Neurobiol Aging. 2019. PMID: 30554086 Free article.
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci.
Rostalski H, Hietanen T, Leskelä S, Behánová A, Abdollahzadeh A, Wittrahm R, Mäkinen P, Huber N, Hoffmann D, Solje E, Remes AM, Natunen T, Takalo M, Tohka J, Hiltunen M, Haapasalo A. Rostalski H, et al. Among authors: wittrahm r. Front Neurol. 2020 Oct 6;11:550140. doi: 10.3389/fneur.2020.550140. eCollection 2020. Front Neurol. 2020. PMID: 33123074 Free PMC article.