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2015 2
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Page 1
Programming inactive RNA-binding small molecules into bioactive degraders.
Tong Y, Lee Y, Liu X, Childs-Disney JL, Suresh BM, Benhamou RI, Yang C, Li W, Costales MG, Haniff HS, Sievers S, Abegg D, Wegner T, Paulisch TO, Lekah E, Grefe M, Crynen G, Van Meter M, Wang T, Gibaut QMR, Cleveland JL, Adibekian A, Glorius F, Waldmann H, Disney MD. Tong Y, et al. Among authors: benhamou ri. Nature. 2023 Jun;618(7963):169-179. doi: 10.1038/s41586-023-06091-8. Epub 2023 May 24. Nature. 2023. PMID: 37225982 Free PMC article.
Targeting MicroRNAs with Small Molecules.
Tadesse K, Benhamou RI. Tadesse K, et al. Among authors: benhamou ri. Noncoding RNA. 2024 Mar 14;10(2):17. doi: 10.3390/ncrna10020017. Noncoding RNA. 2024. PMID: 38525736 Free PMC article. Review.
A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome.
Bush JA, Meyer SM, Fuerst R, Tong Y, Li Y, Benhamou RI, Aikawa H, Zanon PRA, Gibaut QMR, Angelbello AJ, Gendron TF, Zhang YJ, Petrucelli L, Heick Jensen T, Childs-Disney JL, Disney MD. Bush JA, et al. Among authors: benhamou ri. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2210532119. doi: 10.1073/pnas.2210532119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409902 Free PMC article.
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.
Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, Baisden J, Crynen G, Meyer SM, Cameron MD, Chatterjee AK, Adibekian A, Childs-Disney JL, Disney MD. Zhang P, et al. Among authors: benhamou ri. J Am Chem Soc. 2021 Aug 25;143(33):13044-13055. doi: 10.1021/jacs.1c02248. Epub 2021 Aug 13. J Am Chem Soc. 2021. PMID: 34387474 Free PMC article.
Methods for the study of ribonuclease targeting chimeras (RiboTACs).
Springer NA, Meyer SM, Taghavi A, Benhamou RI, Tong Y, Childs-Disney JL, Disney MD. Springer NA, et al. Among authors: benhamou ri. Methods Enzymol. 2023;692:249-298. doi: 10.1016/bs.mie.2023.06.006. Epub 2023 Sep 13. Methods Enzymol. 2023. PMID: 37925183
30 results