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Page 1
Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.
Bioorg Med Chem. 2015 Dec 15;23(24):7497-520. doi: 10.1016/j.bmc.2015.10.012.
Bioorg Med Chem. 2015.
PMID: 26775540
Free PMC article.
Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment.
Liu L, Schuetze R, Gerberich JL, Lopez R, Odutola SO, Tanpure RP, Charlton-Sevcik AK, Tidmore JK, Taylor EA, Kapur P, Hammers H, Trawick ML, Pinney KG, Mason RP.
Liu L, et al. Among authors: lopez r.
Cancers (Basel). 2022 Aug 30;14(17):4208. doi: 10.3390/cancers14174208.
Cancers (Basel). 2022.
PMID: 36077745
Free PMC article.
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Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG.
Hadimani MB, et al. Among authors: lopez r.
J Nat Prod. 2013 Sep 27;76(9):1668-78. doi: 10.1021/np400374w. Epub 2013 Sep 9.
J Nat Prod. 2013.
PMID: 24016002
Free PMC article.
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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
Maguire CJ, Chen Z, Mocharla VP, Sriram M, Strecker TE, Hamel E, Zhou H, Lopez R, Wang Y, Mason RP, Chaplin DJ, Trawick ML, Pinney KG.
Maguire CJ, et al. Among authors: lopez r.
Medchemcomm. 2018 Aug 24;9(10):1649-1662. doi: 10.1039/c8md00322j. eCollection 2018 Oct 1.
Medchemcomm. 2018.
PMID: 30429970
Free PMC article.
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The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML.
Strecker TE, et al. Among authors: lopez r.
Cancer Lett. 2015 Dec 1;369(1):229-41. doi: 10.1016/j.canlet.2015.08.021. Epub 2015 Sep 1.
Cancer Lett. 2015.
PMID: 26325604
Free PMC article.
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Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG.
Devkota L, et al. Among authors: lopez r.
Bioorg Med Chem. 2016 Mar 1;24(5):938-956. doi: 10.1016/j.bmc.2016.01.007. Epub 2016 Jan 6.
Bioorg Med Chem. 2016.
PMID: 26852340
Free PMC article.
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Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and (19)F MRI.
Zhou H, Hallac RR, Lopez R, Denney R, MacDonough MT, Li L, Liu L, Graves EE, Trawick ML, Pinney KG, Mason RP.
Zhou H, et al. Among authors: lopez r.
Am J Nucl Med Mol Imaging. 2015 Jan 15;5(2):143-53. eCollection 2015.
Am J Nucl Med Mol Imaging. 2015.
PMID: 25973335
Free PMC article.
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