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SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters.
Groß E, Hilger RA, Schümann FL, Bauer M, Bouska A, Rohde C, Willscher E, Lützkendorf J, Müller LP, Edemir B, Mueller T, Herling M, Binder M, Wickenhauser C, Iqbal J, Posern G, Weber T. Groß E, et al. Among authors: hilger ra. Cancers (Basel). 2023 Jun 3;15(11):3043. doi: 10.3390/cancers15113043. Cancers (Basel). 2023. PMID: 37297005 Free PMC article.
TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer.
Zhao B, Dierichs L, Gu JN, Trajkovic-Arsic M, Axel Hilger R, Savvatakis K, Vega-Rubin-de-Celis S, Liffers ST, Peña-Llopis S, Behrens D, Hahn S, Siveke JT, Lueong SS. Zhao B, et al. Among authors: axel hilger r. Cell Death Discov. 2020 Mar 11;6:12. doi: 10.1038/s41420-020-0246-7. eCollection 2020. Cell Death Discov. 2020. PMID: 32194992 Free PMC article.
Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells.
Melnikova M, Wauer US, Mendus D, Hilger RA, Oliver TG, Mercer K, Gohlke BO, Erdmann K, Niederacher D, Neubauer H, Buderath P, Wimberger P, Kuhlmann JD, Thomale J. Melnikova M, et al. Among authors: hilger ra. Mol Oncol. 2020 Apr;14(4):686-703. doi: 10.1002/1878-0261.12648. Epub 2020 Mar 10. Mol Oncol. 2020. PMID: 32037720 Free PMC article.
Variability in fluorouracil exposure during continuous intravenous infusion.
Hendrayana T, Kurth V, Krolop L, Kenny P, Hilger RA, Schmidt-Wolf IG, Ko YD, Jaehde U. Hendrayana T, et al. Among authors: hilger ra. Int J Clin Pharmacol Ther. 2012 Jan;50(1):82-4. doi: 10.5414/cpp50082. Int J Clin Pharmacol Ther. 2012. PMID: 22192656 Free article. No abstract available.