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High-throughput functional annotation of natural products by integrated activity profiling.
Hight SK, Clark TN, Kurita KL, McMillan EA, Bray W, Shaikh AF, Khadilkar A, Haeckl FPJ, Carnevale-Neto F, La S, Lohith A, Vaden RM, Lee J, Wei S, Lokey RS, White MA, Linington RG, MacMillan JB. Hight SK, et al. Among authors: vaden rm. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2208458119. doi: 10.1073/pnas.2208458119. Epub 2022 Nov 30. Proc Natl Acad Sci U S A. 2022. PMID: 36449542 Free PMC article.
Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.
McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni H, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA. McMillan EA, et al. Among authors: vaden rm. Cell. 2018 May 3;173(4):864-878.e29. doi: 10.1016/j.cell.2018.03.028. Epub 2018 Apr 19. Cell. 2018. PMID: 29681454 Free PMC article.
A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A.
Vaden RM, Guillen KP, Salvant JM, Santiago CB, Gibbons JB, Pathi SS, Arunachalam S, Sigman MS, Looper RE, Welm BE. Vaden RM, et al. ACS Chem Biol. 2019 Jan 18;14(1):106-117. doi: 10.1021/acschembio.8b00977. Epub 2019 Jan 8. ACS Chem Biol. 2019. PMID: 30571086 Free PMC article.
A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery.
McMillan EA, Kwon G, Clemenceau JR, Fisher KW, Vaden RM, Shaikh AF, Neilsen BK, Kelly D, Potts MB, Sung YJ, Mendiratta S, Hight SK, Lee Y, MacMillan JB, Lewis RE, Kim HS, White MA. McMillan EA, et al. Among authors: vaden rm. Cell Chem Biol. 2019 Oct 17;26(10):1380-1392.e6. doi: 10.1016/j.chembiol.2019.07.008. Epub 2019 Aug 1. Cell Chem Biol. 2019. PMID: 31378711 Free PMC article.