Quantile modeling through multivariate log-normal/independent linear regression models with application to newborn data

Biom J. 2021 Aug;63(6):1290-1308. doi: 10.1002/bimj.202000200. Epub 2021 May 5.

Abstract

In this article, we propose and study the class of multivariate log-normal/independent distributions and linear regression models based on this class. The class of multivariate log-normal/independent distributions is very attractive for robust statistical modeling because it includes several heavy-tailed distributions suitable for modeling correlated multivariate positive data that are skewed and possibly heavy-tailed. Besides, expectation-maximization (EM)-type algorithms can be easily implemented for maximum likelihood estimation. We model the relationship between quantiles of the response variables and a set of explanatory variables, compute the maximum likelihood estimates of parameters through EM-type algorithms, and evaluate the model fitting based on Mahalanobis-type distances. The satisfactory performance of the quantile estimation is verified by simulation studies. An application to newborn data is presented and discussed.

Keywords: EM algorithm; multivariate linear regression; multivariate normal/independent distribution; newborn; quantile modeling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Humans
  • Infant, Newborn
  • Likelihood Functions
  • Linear Models
  • Models, Statistical*
  • Normal Distribution