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Year Number of Results
2007 1
2008 1
2010 2
2011 2
2012 2
2013 4
2014 1
2015 1
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2018 6
2019 2
2020 6
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2022 3
2023 3
2024 2

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36 results

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Page 1
Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders.
García-Gutiérrez MS, Navarrete F, Gasparyan A, Austrich-Olivares A, Sala F, Manzanares J. García-Gutiérrez MS, et al. Biomolecules. 2020 Nov 19;10(11):1575. doi: 10.3390/biom10111575. Biomolecules. 2020. PMID: 33228239 Free PMC article. Review.
In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB(1)r and CB(2)r), 5-HT(1A) receptor and neurogenesis factors. Preliminary clinical trials also support the efficacy of CBD as an anxiolytic, …
In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB(1)r an …
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.
Zeiser R, von Bubnoff N, Butler J, Mohty M, Niederwieser D, Or R, Szer J, Wagner EM, Zuckerman T, Mahuzier B, Xu J, Wilke C, Gandhi KK, Socié G; REACH2 Trial Group. Zeiser R, et al. N Engl J Med. 2020 May 7;382(19):1800-1810. doi: 10.1056/NEJMoa1917635. Epub 2020 Apr 22. N Engl J Med. 2020. PMID: 32320566 Clinical Trial.
Role of Cannabinoid CB2 Receptor in Alcohol Use Disorders: From Animal to Human Studies.
García-Gutiérrez MS, Navarrete F, Gasparyan A, Navarro D, Morcuende Á, Femenía T, Manzanares J. García-Gutiérrez MS, et al. Int J Mol Sci. 2022 May 25;23(11):5908. doi: 10.3390/ijms23115908. Int J Mol Sci. 2022. PMID: 35682586 Free PMC article. Review.
Pharmacological approaches demonstrated that the activation or blockade of CB(2)r modulated different alcohol-addictive behaviors. Rodent models of alcoholism revealed significant alterations of CB(2)r in brain areas of the reward system. In addition, mice lacking C …
Pharmacological approaches demonstrated that the activation or blockade of CB(2)r modulated different alcohol-addictive behaviors. Ro …
Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice.
Ortega-Alvaro A, Aracil-Fernández A, García-Gutiérrez MS, Navarrete F, Manzanares J. Ortega-Alvaro A, et al. Neuropsychopharmacology. 2011 Jun;36(7):1489-504. doi: 10.1038/npp.2011.34. Epub 2011 Mar 23. Neuropsychopharmacology. 2011. PMID: 21430651 Free PMC article.
Chronic risperidone treatment in WT mice left alpha(2C)r gene expression unchanged, decreased D(2)r gene expression (15 mug/kg), and decreased 5-HT(2C)r and 5-HT(2A)r in PFC and DR. In CB(2)KO, the gene expression of D(2)r in the PFC, of alpha(2 …
Chronic risperidone treatment in WT mice left alpha(2C)r gene expression unchanged, decreased D(2)r gene expression (15 mug/kg …
Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson's Disease.
Navarrete F, García-Gutiérrez MS, Aracil-Fernández A, Lanciego JL, Manzanares J. Navarrete F, et al. Neurotherapeutics. 2018 Apr;15(2):459-469. doi: 10.1007/s13311-018-0603-x. Neurotherapeutics. 2018. PMID: 29352424 Free PMC article.
CB(1)r, CB(2A)r, and MAGL gene expressions were evaluated by real-time polymerase chain reaction (real-time PCR) using Taqman assays. ...The results of the present study suggest that CB(1)r, CB(2)r, and MAGL are closely related to the neuropathological …
CB(1)r, CB(2A)r, and MAGL gene expressions were evaluated by real-time polymerase chain reaction (real-time PCR) using Taqman …
Cannabidiol reduces ethanol consumption, motivation and relapse in mice.
Viudez-Martínez A, García-Gutiérrez MS, Navarrón CM, Morales-Calero MI, Navarrete F, Torres-Suárez AI, Manzanares J. Viudez-Martínez A, et al. Addict Biol. 2018 Jan;23(1):154-164. doi: 10.1111/adb.12495. Epub 2017 Feb 13. Addict Biol. 2018. PMID: 28194850
Gene expression analyses of tyrosine hydroxylase in ventral tegmental area and mu-opioid (Oprm1), cannabinoid (CB(1) r and CB(2) r) and GPR55 receptors in nucleus accumbens (NAcc) were carried out by real-time polymerase chain reaction. ...Furthermore, the administr …
Gene expression analyses of tyrosine hydroxylase in ventral tegmental area and mu-opioid (Oprm1), cannabinoid (CB(1) r and CB(2) r …
Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings.
Huber H, Blennow K, Zetterberg H, Boada M, Jeromin A, Weninger H, Nuñez-Llaves R, Aguilera N, Ramis M, Simrén J, Nilsson J, Lantero-Rodriguez J, Orellana A, García-Gutiérrez F, Morató X, Ashton NJ, Montoliu-Gaya L. Huber H, et al. Alzheimers Dement. 2024 Apr;20(4):2340-2352. doi: 10.1002/alz.13697. Epub 2024 Jan 29. Alzheimers Dement. 2024. PMID: 38284555 Free PMC article.
Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol.
Navarrete F, García-Gutiérrez MS, Manzanares J. Navarrete F, et al. Biochem Pharmacol. 2018 Nov;157:227-234. doi: 10.1016/j.bcp.2018.07.041. Epub 2018 Jul 29. Biochem Pharmacol. 2018. PMID: 30063884
The pharmacological manipulation of cannabinoid CB1 receptor (CB(1)r) in alcoholic patients provided discouraging results, so researchers have recently turned their attention to the cannabinoid CB2 receptor (CB(2)r). In this regard, the present study aims to charact …
The pharmacological manipulation of cannabinoid CB1 receptor (CB(1)r) in alcoholic patients provided discouraging results, so researc …
Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA.
Sánchez R, Dorado S, Ruíz-Heredia Y, Martín-Muñoz A, Rosa-Rosa JM, Ribera J, García O, Jimenez-Ubieto A, Carreño-Tarragona G, Linares M, Rufián L, Juárez A, Carrillo J, Espino MJ, Cáceres M, Expósito S, Cuevas B, Vanegas R, Casado LF, Torrent A, Zamora L, Mercadal S, Coll R, Cervera M, Morgades M, Hernández-Rivas JÁ, Bravo P, Serí C, Anguita E, Barragán E, Sargas C, Ferrer-Marín F, Sánchez-Calero J, Sevilla J, Ruíz E, Villalón L, Del Mar Herráez M, Riaza R, Magro E, Steegman JL, Wang C, de Toledo P, García-Gutiérrez V, Ayala R, Ribera JM, Barrio S, Martínez-López J. Sánchez R, et al. Sci Rep. 2022 Jul 29;12(1):13057. doi: 10.1038/s41598-022-17271-3. Sci Rep. 2022. PMID: 35906470 Free PMC article.
The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. ...

The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-

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36 results