A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Lyon M, Li P, Ferreira JJ, Lazarenko RM, Kharade SV, Kramer M, McClenahan SJ, Days E, Bauer JA, Spitznagel BD, Weaver CD, Borrego Alvarez A, Puga Molina LC, Lybaert P, Khambekar S, Liu A, Lindsley CW, Denton J, Santi CM.
Lyon M, et al.
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212338120. doi: 10.1073/pnas.2212338120. Epub 2023 Jan 17.
Proc Natl Acad Sci U S A. 2023.
PMID: 36649421
Free PMC article.
In human sperm, it has long been unclear whether hyperpolarization depends on SLO3 or the ubiquitous K(+) channel SLO1 [N. Mannowetz, N. M. Naidoo, S. A. S. Choo, J. F. Smith, P. V. Lishko, Elife 2, e01009 (2013), C. Brenker et al., Elife 3, e01438 (2014), and S …
In human sperm, it has long been unclear whether hyperpolarization depends on SLO3 or the ubiquitous K(+) channel SLO1 [N. Mannowetz, N. M. …