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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. Borriello F, et al. Cell. 2022 Feb 17;185(4):614-629.e21. doi: 10.1016/j.cell.2022.01.009. Epub 2022 Feb 10. Cell. 2022. PMID: 35148840 Free PMC article.
High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy.
Chen G, Shrock EL, Li MZ, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Phipatanakul W, Schneider L, Oettgen HC, Elledge SJ. Chen G, et al. Cell Rep Med. 2021 Oct 19;2(10):100410. doi: 10.1016/j.xcrm.2021.100410. eCollection 2021 Oct 19. Cell Rep Med. 2021. PMID: 34755130 Free PMC article. Clinical Trial.
WWOX, the FRA16D gene: A target of and a contributor to genomic instability.
Hussain T, Liu B, Shrock MS, Williams T, Aldaz CM. Hussain T, et al. Genes Chromosomes Cancer. 2019 May;58(5):324-338. doi: 10.1002/gcc.22693. Epub 2018 Dec 26. Genes Chromosomes Cancer. 2019. PMID: 30350478 Review.
WWOX is also a common target for translocations in multiple myeloma. By mapping R-loop (RNA:DNA hybrid) forming sequences (RFLS) we observe this to be a consistent feature aligning with germline and somatic CNV break points at the edges and core of FRA16D spanning from int …
WWOX is also a common target for translocations in multiple myeloma. By mapping R-loop (RNA:DNA hybrid) forming sequences (RFLS) we o …
Atomically accurate de novo design of single-domain antibodies.
Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R, Shrock EL, Leung PJY, Huang B, Goreshnik I, Ault R, Carr KD, Singer B, Criswell C, Vafeados D, Sanchez MG, Kim HM, Torres SV, Chan S, Baker D. Bennett NR, et al. bioRxiv [Preprint]. 2024 Mar 18:2024.03.14.585103. doi: 10.1101/2024.03.14.585103. bioRxiv. 2024. PMID: 38562682 Free PMC article. Preprint.
Effect of specific non-pharmaceutical intervention policies on SARS-CoV-2 transmission in the counties of the United States.
Yang B, Huang AT, Garcia-Carreras B, Hart WE, Staid A, Hitchings MDT, Lee EC, Howe CJ, Grantz KH, Wesolowksi A, Lemaitre JC, Rattigan S, Moreno C, Borgert BA, Dale C, Quigley N, Cummings A, McLorg A, LoMonaco K, Schlossberg S, Barron-Kraus D, Shrock H; UFCOVID Interventions Team; Lessler J, Laird CD, Cummings DAT. Yang B, et al. Nat Commun. 2021 Jun 11;12(1):3560. doi: 10.1038/s41467-021-23865-8. Nat Commun. 2021. PMID: 34117244 Free PMC article.
We estimated weekly values of the effective basic reproductive number (R(eff)) using a mechanistic metapopulation model and associated these with county-level characteristics and NPIs in the United States (US). Interventions that included school and leisure activities clos …
We estimated weekly values of the effective basic reproductive number (R(eff)) using a mechanistic metapopulation model and associate …
Dynamical symmetry breaking of extended gauge symmetries.
Appelquist T, Shrock R. Appelquist T, et al. Phys Rev Lett. 2003 May 23;90(20):201801. doi: 10.1103/PhysRevLett.90.201801. Epub 2003 May 20. Phys Rev Lett. 2003. PMID: 12785882 Free article.
We construct asymptotically free gauge theories exhibiting dynamical breaking of the left-right gauge group G(LR)=SU(3)(c) x SU(2)(L) x SU(2)(R) x U(1)(B-L), and its extension to the Pati-Salam gauge group G(422)=SU(4)(PS) x SU(2)(L) x SU(2)(R). ...
We construct asymptotically free gauge theories exhibiting dynamical breaking of the left-right gauge group G(LR)=SU(3)(c) x SU(2)(L) x SU(2 …