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Purification and characterization of recombinant cystic fibrosis transmembrane conductance regulator from Chinese hamster ovary and insect cells.
O'Riordan CR, Erickson A, Bear C, Li C, Manavalan P, Wang KX, Marshall J, Scheule RK, McPherson JM, Cheng SH, et al. O'Riordan CR, et al. J Biol Chem. 1995 Jul 14;270(28):17033-43. doi: 10.1074/jbc.270.28.17033. J Biol Chem. 1995. PMID: 7542655 Free article.
Insect CFTR from Sf9 cells was purified using a modification of the method of Bear et al. (Bear, C. E., Li, C., Kartner, N., Bridges, R. J., Jensen, T. J., Ramjeesingh, M. and Riordan, J. R. (1992) Cell 68, 809-818), which included extraction with sodium dode …
Insect CFTR from Sf9 cells was purified using a modification of the method of Bear et al. (Bear, C. E., Li, C., Kartner, N., Bridges, R …
The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
Broadbent SD, Ramjeesingh M, Bear CE, Argent BE, Linsdell P, Gray MA. Broadbent SD, et al. Pflugers Arch. 2015 Aug;467(8):1783-94. doi: 10.1007/s00424-014-1618-8. Epub 2014 Oct 4. Pflugers Arch. 2015. PMID: 25277268 Free PMC article.
CFTR activity is regulated by phosphorylation of its cytosolic regulatory (R) domain, and ATP binding and hydrolysis at two nucleotide-binding domains (NBDs). ...
CFTR activity is regulated by phosphorylation of its cytosolic regulatory (R) domain, and ATP binding and hydrolysis at two nucleotid …
The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.
Pasyk S, Molinski S, Ahmadi S, Ramjeesingh M, Huan LJ, Chin S, Du K, Yeger H, Taylor P, Moran MF, Bear CE. Pasyk S, et al. Proteomics. 2015 Jan;15(2-3):447-61. doi: 10.1002/pmic.201400218. Epub 2014 Dec 17. Proteomics. 2015. PMID: 25330774
In this study, we asked if there are allosteric effects of F508del on the phosphorylation-regulated R domain. To identify defects in the R domain, we compared the phosphorylation status at protein kinase A sites in the R domain of Wt and F508del-CFTR. ...
In this study, we asked if there are allosteric effects of F508del on the phosphorylation-regulated R domain. To identify defects in …
Phosphorylation-induced conformational changes of cystic fibrosis transmembrane conductance regulator monitored by attenuated total reflection-Fourier transform IR spectroscopy and fluorescence spectroscopy.
Grimard V, Li C, Ramjeesingh M, Bear CE, Goormaghtigh E, Ruysschaert JM. Grimard V, et al. J Biol Chem. 2004 Feb 13;279(7):5528-36. doi: 10.1074/jbc.M311014200. Epub 2003 Dec 2. J Biol Chem. 2004. PMID: 14660584 Free article.
We analyzed the effect of protein kinase A (PKA) phosphorylation on the structure of purified and reconstituted CFTR protein. 1H/2H exchange monitored by attenuated total reflection Fourier transform IR spectroscopy demonstrates that CFTR is highly accessible to aqueous medium. P …
We analyzed the effect of protein kinase A (PKA) phosphorylation on the structure of purified and reconstituted CFTR protein. 1H/2H exchange …
The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.
Stratford FL, Ramjeesingh M, Cheung JC, Huan LJ, Bear CE. Stratford FL, et al. Biochem J. 2007 Jan 15;401(2):581-6. doi: 10.1042/BJ20060968. Biochem J. 2007. PMID: 16989640 Free PMC article.
CFTR (cystic fibrosis transmembrane conductance regulator), a member of the ABC (ATP-binding cassette) superfamily of membrane proteins, possesses two NBDs (nucleotide-binding domains) in addition to two MSDs (membrane spanning domains) and the regulatory 'R' domain. The t …
CFTR (cystic fibrosis transmembrane conductance regulator), a member of the ABC (ATP-binding cassette) superfamily of membrane proteins, pos …
The red cell band 3 protein: its role in anion transport.
Rothstein A, Ramjeesingh M. Rothstein A, et al. Philos Trans R Soc Lond B Biol Sci. 1982 Dec 1;299(1097):497-507. doi: 10.1098/rstb.1982.0147. Philos Trans R Soc Lond B Biol Sci. 1982. PMID: 6130542
11 results