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Meta-Analysis of 26 638 Individuals Identifies Two Genetic Loci Associated With Left Ventricular Ejection Fraction.
Choquet H, Thai KK, Jiang C, Ranatunga DK, Hoffmann TJ, Go AS, Lindsay AC, Ehm MG, Waterworth DM, Risch N, Schaefer C. Choquet H, et al. Circ Genom Precis Med. 2020 Aug;13(4):e002804. doi: 10.1161/CIRCGEN.119.002804. Epub 2020 Jun 30. Circ Genom Precis Med. 2020. PMID: 32605384 Free PMC article.
RESULTS: A meta-analysis combining results from Genetic Epidemiology Research on Adult Health and Aging and UK Biobank identified a novel locus: TMEM40 on chromosome 3p25 (rs11719526; beta=0.47 and P=3.1010(-8)) that replicated in Biobank Japan and confirmed recent finding …
RESULTS: A meta-analysis combining results from Genetic Epidemiology Research on Adult Health and Aging and UK Biobank identified a novel lo …
Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.
Oni-Orisan A, Hoffmann TJ, Ranatunga D, Medina MW, Jorgenson E, Schaefer C, Krauss RM, Iribarren C, Risch N. Oni-Orisan A, et al. Circ Genom Precis Med. 2018 Sep;11(9):e002043. doi: 10.1161/CIRCGEN.117.002043. Circ Genom Precis Med. 2018. PMID: 30354326 Free PMC article.
RESULTS: Defined daily dose and LDL-C response was associated in a log-linear relationship (beta, -6.17; SE, 0.09; P<10(-300)) which remained significant after adjusting for prespecified covariates (adjusted beta, -5.59; SE, 0.12; P<10(-300)). ...Based on a va …
RESULTS: Defined daily dose and LDL-C response was associated in a log-linear relationship (beta, -6.17; SE, 0.09; P<10(-300)) whi …