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Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts.
Lemmens-Gruber R, Zilberszac A, Heistracher P. Lemmens-Gruber R, et al. Arch Int Pharmacodyn Ther. 1996 Jan-Feb;331(1):46-58. Arch Int Pharmacodyn Ther. 1996. PMID: 8896710
.-(+/-)-sotalol hydrochloride (n = 28; 20 mumol/l: 0/28, 40 mumol/l: 9/28, 80 mumol/l: 20/28), (R)(+)-sotalol hydrochloride (n = 12; 40 mumol/l: 1/12, 80 mumol/l: 4/12), and (S)(-)-sotalol hydrochloride (n = 10, 40 mumol/l: 1/10, 80 mumol/l: 4/10). ...
.-(+/-)-sotalol hydrochloride (n = 28; 20 mumol/l: 0/28, 40 mumol/l: 9/28, 80 mumol/l: 20/28), (R)(+)-sotalol hydrochloride (n = 12; …
Improved synthesis and pharmacologic activity of the enantiomers of a new benzofurane type antiarrhythmic compound.
Ecker G, Fleischhacker W, Helml T, Noe CR, Scasny S, Lemmens-Gruber R, Studenik C, Marei H, Heistracher P. Ecker G, et al. Chirality. 1994;6(4):329-36. doi: 10.1002/chir.530060417. Chirality. 1994. PMID: 8068490
Reaction with propylamine and cleavage of the protective group gave (R)-1 and (S)-1, respectively. Enantiomeric purity was confirmed using a direct HPLC method with rsp-cyclodextrine as stationary phase. ...
Reaction with propylamine and cleavage of the protective group gave (R)-1 and (S)-1, respectively. Enantiomeric purity was confirmed …