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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2005 1
2007 3
2009 1
2010 1
2011 1
2012 1
2013 1
2014 1
2018 1
2019 1
2020 1
2021 2
2022 1
2023 2
2024 1

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19 results

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Page 1
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network; Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, et al. N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112383 Free PMC article. Clinical Trial.
Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress.
Preninka AI, Kuriya K, Yazawa K, Yoshii M, Yanase Y, Jockers R, Dam J, Hosoi T, Ozawa K. Preninka AI, et al. PLoS One. 2022 Dec 13;17(12):e0278965. doi: 10.1371/journal.pone.0278965. eCollection 2022. PLoS One. 2022. PMID: 36512575 Free PMC article.
Leptin is an anti-obesity protein and its action is mainly mediated by the activation of its Ob-R receptor in neuronal cells. The inability of leptin to induce activation of its specific signaling pathways, especially under endoplasmic reticulum stress, leads to the leptin …
Leptin is an anti-obesity protein and its action is mainly mediated by the activation of its Ob-R receptor in neuronal cells. The ina …
Multivalent-based drug design applied to serotonin 5-HT(4) receptor oligomers.
Lezoualc'h F, Jockers R, Berque-Bestel I. Lezoualc'h F, et al. Curr Pharm Des. 2009;15(6):719-29. doi: 10.2174/138161209787315602. Curr Pharm Des. 2009. PMID: 19199991 Review.
In this review, key requirements for the successful design and synthesis of GPCR multivalent ligands composed of pharmacophores and a linker will be discussed. We will then focus on the 5-HT(4) receptor (5-HT(4)R), whose ligands emerged as promising drugs for a variety of …
In this review, key requirements for the successful design and synthesis of GPCR multivalent ligands composed of pharmacophores and a linker …
Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay.
Vauthier V, Derviaux C, Douayry N, Roux T, Trinquet E, Jockers R, Dam J. Vauthier V, et al. Anal Biochem. 2013 May 1;436(1):1-9. doi: 10.1016/j.ab.2012.12.013. Epub 2013 Jan 17. Anal Biochem. 2013. PMID: 23333588
Abnormal leptin action is associated with obesity, autoimmune diseases, and cancer. The pharmacological characterization of OB-R and the development of synthetic OB-R ligands are still in their infancy because currently available binding assays are not compatible wi …
Abnormal leptin action is associated with obesity, autoimmune diseases, and cancer. The pharmacological characterization of OB-R and …
Two transmembrane Cys residues are involved in 5-HT4 receptor dimerization.
Berthouze M, Rivail L, Lucas A, Ayoub MA, Russo O, Sicsic S, Fischmeister R, Berque-Bestel I, Jockers R, Lezoualc'h F. Berthouze M, et al. Biochem Biophys Res Commun. 2007 May 11;356(3):642-7. doi: 10.1016/j.bbrc.2007.03.030. Epub 2007 Mar 12. Biochem Biophys Res Commun. 2007. PMID: 17379184
The 5-HT(4)R exists as a constitutive dimer but its molecular determinants are still unknown. Using co-immunoprecipitation and Bioluminescence Resonance Energy Transfer (BRET) techniques, we show here that 5-HT(4)R homodimerization but not 5-HT(4)R-beta(2) ad …
The 5-HT(4)R exists as a constitutive dimer but its molecular determinants are still unknown. Using co-immunoprecipitation and Biolum …
Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway.
Séron K, Couturier C, Belouzard S, Bacart J, Monté D, Corset L, Bocquet O, Dam J, Vauthier V, Lecœur C, Bailleul B, Hoflack B, Froguel P, Jockers R, Rouillé Y. Séron K, et al. J Biol Chem. 2011 May 20;286(20):17968-81. doi: 10.1074/jbc.M111.224857. Epub 2011 Mar 22. J Biol Chem. 2011. PMID: 21454707 Free PMC article.
Endospanin-1 is a negative regulator of the cell surface expression of leptin receptor (OB-R), and endospanin-2 is a homologue of unknown function. We investigated the mechanism for endospanin-1 action in regulating OB-R cell surface expression. ...Overexpression of …
Endospanin-1 is a negative regulator of the cell surface expression of leptin receptor (OB-R), and endospanin-2 is a homologue of unk …
19 results