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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Lyon M, Li P, Ferreira JJ, Lazarenko RM, Kharade SV, Kramer M, McClenahan SJ, Days E, Bauer JA, Spitznagel BD, Weaver CD, Borrego Alvarez A, Puga Molina LC, Lybaert P, Khambekar S, Liu A, Lindsley CW, Denton J, Santi CM. Lyon M, et al. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212338120. doi: 10.1073/pnas.2212338120. Epub 2023 Jan 17. Proc Natl Acad Sci U S A. 2023. PMID: 36649421 Free PMC article.
In human sperm, it has long been unclear whether hyperpolarization depends on SLO3 or the ubiquitous K(+) channel SLO1 [N. Mannowetz, N. M. Naidoo, S. A. S. Choo, J. F. Smith, P. V. Lishko, Elife 2, e01009 (2013), C. Brenker et al., Elife 3, e01438 (2014), and S …
In human sperm, it has long been unclear whether hyperpolarization depends on SLO3 or the ubiquitous K(+) channel SLO1 [N. Mannowetz, N. M. …
Mortality after surgery in Europe: a 7 day cohort study.
Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent JL, Hoeft A, Rhodes A; European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and the European Society of Anaesthesiology. Pearse RM, et al. Lancet. 2012 Sep 22;380(9847):1059-65. doi: 10.1016/S0140-6736(12)61148-9. Lancet. 2012. PMID: 22998715 Free PMC article.
Secondary outcome measures were duration of hospital stay and admission to critical care. We used chi(2) and Fisher's exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. ...
Secondary outcome measures were duration of hospital stay and admission to critical care. We used chi(2) and Fisher's exact tests to …
Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival.
Poças J, Marques C, Gomes C, Otake AH, Pinto F, Ferreira M, Silva T, Faria-Ramos I, Matos R, Ribeiro AR, Senra E, Cavadas B, Batista S, Maia J, Macedo JA, Lima L, Afonso LP, Ferreira JA, Santos LL, Polónia A, Osório H, Belting M, Reis CA, Costa-Silva B, Magalhães A. Poças J, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2214853120. doi: 10.1073/pnas.2214853120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155874 Free PMC article.
Enantiomeric ratios: Why so many notations?
Tiritan ME, Fernandes C, Maia AS, Pinto M, Cass QB. Tiritan ME, et al. J Chromatogr A. 2018 Sep 28;1569:1-7. doi: 10.1016/j.chroma.2018.07.039. Epub 2018 Jul 11. J Chromatogr A. 2018. PMID: 30025608 Review.
In order to simplify the notations, the use of enantiomeric ratio (e.r.%) as standardization for nonchiroptical methods is proposed....
In order to simplify the notations, the use of enantiomeric ratio (e.r.%) as standardization for nonchiroptical methods is proposed.. …
Biomarkers of Alzheimer's Disease and Cerebrovascular Disease in Relation to Depressive Symptomatology in Individuals With Subjective Cognitive Decline.
Zapater-Fajarí M, Diaz-Galvan P, Cedres N, Rydberg Sterner T, Rydén L, Sacuiu S, Waern M, Zettergren A, Zetterberg H, Blennow K, Kern S, Hidalgo V, Salvador A, Westman E, Skoog I, Ferreira D. Zapater-Fajarí M, et al. J Gerontol A Biol Sci Med Sci. 2024 Feb 1;79(2):glad216. doi: 10.1093/gerona/glad216. J Gerontol A Biol Sci Med Sci. 2024. PMID: 37708068 Free PMC article.
BACKGROUND: Subjective cognitive decline (SCD) has gained recent interest as a potential harbinger of neurodegenerative diseases such as Alzheimer's disease (AD) and cerebrovascular disease (CVD). In addition, SCD can be related to depressive symptomatology. ...
BACKGROUND: Subjective cognitive decline (SCD) has gained recent interest as a potential harbinger of neurodegenerative diseases such as Alz …
Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition.
Venditto I, Luis AS, Rydahl M, Schückel J, Fernandes VO, Vidal-Melgosa S, Bule P, Goyal A, Pires VM, Dourado CG, Ferreira LM, Coutinho PM, Henrissat B, Knox JP, Baslé A, Najmudin S, Gilbert HJ, Willats WG, Fontes CM. Venditto I, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7136-41. doi: 10.1073/pnas.1601558113. Epub 2016 Jun 13. Proc Natl Acad Sci U S A. 2016. PMID: 27298375 Free PMC article.
Here, high throughput screening of 177 protein modules of unknown function was used to determine the complete CBMome of R. flavefaciens The data identified six previously unidentified CBM families that targeted beta-glucans, beta-mannans, and the pectic polysaccharide homo …
Here, high throughput screening of 177 protein modules of unknown function was used to determine the complete CBMome of R. flavefacie …
Modelling the dynamics of dengue real epidemics.
Pinho ST, Ferreira CP, Esteva L, Barreto FR, Morato e Silva VC, Teixeira MG. Pinho ST, et al. Philos Trans A Math Phys Eng Sci. 2010 Dec 28;368(1933):5679-93. doi: 10.1098/rsta.2010.0278. Philos Trans A Math Phys Eng Sci. 2010. PMID: 21078642
Using real data, we obtain the force of infection, lambda, and the basic reproductive number, R(0), for both epidemics. We also obtain the time evolution of the effective reproduction number, R(t), which results in a very suitable measure to compare the patterns of …
Using real data, we obtain the force of infection, lambda, and the basic reproductive number, R(0), for both epidemics. We also obtai …
Bifunctionality of a biofilm matrix protein controlled by redox state.
Arnaouteli S, Ferreira AS, Schor M, Morris RJ, Bromley KM, Jo J, Cortez KL, Sukhodub T, Prescott AR, Dietrich LEP, MacPhee CE, Stanley-Wall NR. Arnaouteli S, et al. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6184-E6191. doi: 10.1073/pnas.1707687114. Epub 2017 Jul 11. Proc Natl Acad Sci U S A. 2017. PMID: 28698374 Free PMC article.
In vitro and in vivo acute toxicity of an artificial butter flavoring.
Nunes NMF, do Nascimento Silva J, Conceição MLP, da Costa Júnior JS, da Silva Sousa E, das Dores Alves de Oliveira M, Maria das Graças Lopes Citó A, Dittz D, Peron AP, Ferreira PMP. Nunes NMF, et al. J Toxicol Environ Health A. 2023 Mar 19;86(6):181-197. doi: 10.1080/15287394.2023.2172502. Epub 2023 Feb 15. J Toxicol Environ Health A. 2023. PMID: 36794368
For the first time, the ethyl butanoate was found as the main compound of a butter flavoring (97.75%) and 24 h-toxicity assay employing Artemia salina larvae revealed a linear effect and LC(50) value of 14.7 (13.7-15.7) mg/ml (R(2) = 0.9448). Previous reports about higher …
For the first time, the ethyl butanoate was found as the main compound of a butter flavoring (97.75%) and 24 h-toxicity assay employing Arte …
Development and evaluation of Pirkle-type chiral stationary phase for flash chromatography.
Gonçalves L, Cravo S, Fernandes C, Tiritan ME. Gonçalves L, et al. J Chromatogr A. 2022 Jul 19;1675:463156. doi: 10.1016/j.chroma.2022.463156. Epub 2022 May 18. J Chromatogr A. 2022. PMID: 35623191
For the evaluation of the enantioselective performance of the flash column, the enantiomers of a chiral derivative of xanthone were quantitatively enantioseparated with an average recovery of 70% and an enantiomer ratio (e.r.) of 99% and 97% for each enantiomer. Evaluation …
For the evaluation of the enantioselective performance of the flash column, the enantiomers of a chiral derivative of xanthone were quantita …
29 results