Two new acylated flavonol glycosides from the seeds of Lepidium sativum

Molecules. 2014 Jul 31;19(8):11341-9. doi: 10.3390/molecules190811341.

Abstract

Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1 → 2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1 → 3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 25.36 and 25.08 µM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Flavonols / chemistry*
  • Glycosides / chemistry*
  • Lepidium sativum / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Extracts / chemistry*
  • Seeds / chemistry*

Substances

  • Flavonols
  • Glycosides
  • Plant Extracts