The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis.
Wang Y, Tian Q, Hao Y, Yao W, Lu J, Chen C, Chen X, Lin Y, Huang Q, Xu L, Hu J, Lei S, Wei Z, Luo Y, Li Z, Hu L, Tang J, Wu Q, Zhou X, Wu Y, Yin Z, Xu J, Ye L.
Wang Y, et al. Among authors: wu q.
Nat Immunol. 2022 Feb;23(2):303-317. doi: 10.1038/s41590-021-01090-1. Epub 2021 Dec 23.
Nat Immunol. 2022.
PMID: 34949833
Antigen-specific memory CD4(+) T cells can persist and confer rapid and efficient protection from microbial reinfection. However, the mechanisms underlying the long-term maintenance of the memory CD4(+) T cell pool remain largely unknown. Here, using a mouse model of acute …
Antigen-specific memory CD4(+) T cells can persist and confer rapid and efficient protection from microbial reinfection. However, the mechan …