Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities

Yong-Chao Li; Jing Yang; Yuan-Zeng Zhao; Qin-Di Ma; Ben-Guo Liu; Jun-Liang Sun

doi:10.3390/jof9030374

Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities

J Fungi (Basel). 2023 Mar 19;9(3):374. doi: 10.3390/jof9030374.

Authors

Yong-Chao Li^{1

2}, Jing Yang^{1

2}, Yuan-Zeng Zhao^{1

2}, Qin-Di Ma^{1

2}, Ben-Guo Liu^{2

3}, Jun-Liang Sun^{2

3}

Affiliations

¹ School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China.
² Henan International Joint Laboratory of Plant Genetic Improvement and Soil Remediation, Xinxiang 453003, China.
³ School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China.

Abstract

Six new cytochalasans-namely, aspergicytochalasins A-F (1-6)-together with five known analogs were isolated and characterized from the endophytic fungus Aspergillus sp. from the medicinal plant Lonicera japonica. The structures of the new compounds were established by NMR and MS methods as well as single crystal X-ray diffractions. Compounds 3 and 4 showed weak antibacterial activities to Staphylococcus aureus, with MIC values of 128 and 64 μg/mL, respectively. Compounds 1, 3, 5 and 6 showed inhibitory activities on NO production, with IC₅₀ values less than 40 μM.

Keywords: Aspergillus sp. LE2; NO production inhibition; antibacterial activity; endophytic fungus; isolation and structure elucidation.

Grants and funding

221111110300/Key R&D projects in Henan Province