Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: synthesis, characterization, and their interaction with plasmid DNA

Qiang-Lin Li; Jun Huang; Qin Wang; Ning Jiang; Chuan-Qin Xia; Hong-Hui Lin; Jiang Wu; Xiao-Qi Yu

doi:10.1016/j.bmc.2006.01.069

Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: synthesis, characterization, and their interaction with plasmid DNA

Bioorg Med Chem. 2006 Jun 15;14(12):4151-7. doi: 10.1016/j.bmc.2006.01.069. Epub 2006 Feb 21.

Authors

Qiang-Lin Li¹, Jun Huang, Qin Wang, Ning Jiang, Chuan-Qin Xia, Hong-Hui Lin, Jiang Wu, Xiao-Qi Yu

Affiliation

¹ Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China.

PMID: 16495063
DOI: 10.1016/j.bmc.2006.01.069

Abstract

The synthesis of macrocyclic polyamine monometallic complexes containing imidazolium salt groups was reported. Their interaction with pUC19 plasmid DNA was studied. The result showed that these complexes can catalyze the DNA cleavage with unprecedented reactivity under physiological conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclams
DNA, Bacterial / chemistry*
DNA, Bacterial / drug effects
Heterocyclic Compounds / chemistry*
Imidazolines / chemistry*
Metals, Heavy / chemistry*
Molecular Structure
Organometallic Compounds* / chemical synthesis
Organometallic Compounds* / chemistry
Organometallic Compounds* / pharmacology
Plasmids / chemistry*
Structure-Activity Relationship

Substances

Cyclams
DNA, Bacterial
Heterocyclic Compounds
Imidazolines
Metals, Heavy
Organometallic Compounds
cyclen