Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease.
Xie Y, Pan Y, Chen Q, Chen Y, Chen G, Wang M, Zeng P, Li Z, Li Z, Wang S, Yang H, Liang D.
Xie Y, et al. Among authors: chen q.
Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):9. doi: 10.1167/iovs.64.7.9.
Invest Ophthalmol Vis Sci. 2023.
PMID: 37272763
Free PMC article.
Inhibition of BRD4 both by BD2 selective inhibitor ABBV744 and pan-BET inhibitor JQ1 exerted anti-fibrotic effects, whereas ABBV744 displayed superior anti-fibrotic effects and acceptable safety compared to JQ1. ...
Inhibition of BRD4 both by BD2 selective inhibitor ABBV744 and pan-BET inhibitor JQ1 exerted anti-fibrotic effects, whereas ABBV744 d …