Most of the shale gas production in northwest China is from continental shale. Identifying hydrogeochemical and isotopic indicators of toxic hydraulic fracturing flowback fluids (HFFF) has great significance in assessing the safety of drinking water from shallow groundwater and streamwater. Hydrogeochemical and isotopic data for HFFF from the Dameigou shale formations (Cl/Br ratio (1.81 × 10-4-6.52 × 10-4), Ba/Sr (>0.2), δ11B (-10-1‰), and εSWSr (56-65, where εSWSr is the deviation of the 87Sr/86Sr ratio from that of seawater in parts per 104)) were distinct from data for the background saline shallow groundwater and streamwater before fracturing. Mixing models indicated that inorganic elemental signatures (Br/Cl, Ba/Sr) and isotopic fingerprints (δ11B, εSWSr) can be used to distinguish between HFFF and conventional oil-field brine in shallow groundwater and streamwater. These diagnostic indicators were applied to identify potential releases of HFFF into shallow groundwater and streamwater during fracturing, flowback and storage. The monitored time series data for shallow groundwater and streamwater exhibit no clear trends along mixing curves toward the HFFF end member, indicating that there is no detectable release occurring at present.